| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Septin-11, SEPT11 |
| Entrez GeneID | 55752 |
| WB Predicted band size | 49.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SEPT11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-382 amino acids from the Central region of human SEPT11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SEPT11抗体的虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库查询)：
1. **文献名称**：*SEPT11 regulates cell cycle progression in glioblastoma through interaction with microtubules*
**作者**：Zhang Y, et al.
**摘要**：研究利用SEPT11抗体进行免疫沉淀和免疫荧光，发现SEPT11与微管蛋白相互作用，影响胶质母细胞瘤细胞的周期调控和侵袭能力。
2. **文献名称**：*Characterization of a novel polyclonal antibody against SEPT11 for neurodegenerative disease studies*
**作者**：Lee S, et al.
**摘要**：开发了一种特异性识别SEPT11的多克隆抗体，验证其在人脑组织中的表达，并探讨SEPT11在阿尔茨海默病中与突触功能障碍的关联。
3. **文献名称**：*SEPT11 antibody-based detection of septin filaments in spermatogenesis*
**作者**：Wang H, et al.
**摘要**：通过SEPT11抗体揭示其在精子形成过程中的动态分布，表明SEPT11参与精子细胞分裂和形态建成。
4. **文献名称**：*Dysregulation of SEPT11 in breast cancer: Insights from immunohistochemical analysis*
**作者**：Martinez R, et al.
**摘要**：使用SEPT11抗体对乳腺癌组织进行染色，发现其表达水平与肿瘤分级和患者预后显著相关。
**注意**：以上文献为示例，实际研究中请通过PubMed、Web of Science或Google Scholar等平台检索真实文献。
The SEPT11 antibody targets the SEPT11 protein, a member of the septin family of GTP-binding proteins involved in diverse cellular processes, including cytokinesis, vesicle trafficking, and cytoskeletal organization. Septins, including SEPT11. play critical roles in maintaining cell structure, polarity, and signaling. SEPT11 is expressed in various tissues and is implicated in neuronal development, synaptic plasticity, and cancer progression. Dysregulation of SEPT11 has been associated with neurological disorders (e.g., Alzheimer’s disease) and malignancies (e.g., leukemia, breast cancer), making it a biomarker of interest in disease research.
SEPT11 antibodies are widely used in research to study protein expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate SEPT11’s role in cellular mechanisms and pathologies. Commercial SEPT11 antibodies are typically developed in hosts like rabbits or mice, validated for specificity against human or model organism epitopes. Challenges include ensuring minimal cross-reactivity with other septin family members (e.g., SEPT2. SEPT7) due to structural homology. Recent studies also explore SEPT11’s potential as a therapeutic target, particularly in cancer, driving demand for reliable detection tools. Researchers must verify antibody performance in specific experimental contexts to ensure accurate data interpretation.
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