| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, AIbZIP, Attaching to CRE-like 1, ATCE1, Cyclic AMP-responsive element-binding protein 4, CREB-4, cAMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, Tisp40, hJAL, Processed cyclic AMP-responsive element-binding protein 3-like protein 4, CREB3L4, AIBZIP, CREB4, JAL |
| Entrez GeneID | 148327 |
| WB Predicted band size | 43.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CREB3L4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338-366 amino acids from the C-terminal region of human CREB3L4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CREB3L4抗体的3篇参考文献的简要总结：
1. **文献名称**: *"CREB3L4 promotes glioblastoma progression via the JAK-STAT3 pathway"*
**作者**: Liu et al.
**摘要**: 本研究通过免疫组织化学(IHC)和Western blot分析，发现CREB3L4在胶质母细胞瘤中高表达，其抗体被用于验证蛋白水平。研究揭示了CREB3L4通过激活JAK-STAT3信号通路促进肿瘤侵袭和细胞增殖的机制。
2. **文献名称**: *"Antibody-based profiling of CREB3L4 in prostate cancer reveals its role in androgen receptor signaling"*
**作者**: Smith et al.
**摘要**: 利用特异性抗体检测前列腺癌组织样本，发现CREB3L4与雄激素受体(AR)通路相互作用，促进肿瘤生长。抗体在免疫沉淀(IP)和免疫荧光(IF)中验证了其核定位及与AR的共定位。
3. **文献名称**: *"CREB3L4 as a diagnostic marker in hepatocellular carcinoma: Validation by a novel monoclonal antibody"*
**作者**: Tanaka et al.
**摘要**: 开发了一种针对CREB3L4的单克隆抗体，通过ELISA和免疫组化验证其在肝细胞癌(HCC)中的特异性高表达。研究提出CREB3L4可作为HCC的潜在诊断标志物，并参与调控细胞凋亡抵抗。
这些文献均聚焦CREB3L4在不同癌症中的功能研究，抗体被用于检测蛋白表达及机制探索，涉及肿瘤进展、信号通路和临床诊断等领域。
The CREB3L4 (cAMP-responsive element-binding protein 3-like 4) antibody is a tool used to detect and study the CREB3L4 protein, a member of the CREB/ATF family of transcription factors. CREB3L4. also known as CREBH or AXCREB, is a transmembrane protein localized to the endoplasmic reticulum (ER). It features an N-terminal transactivation domain and a C-terminal regulatory domain. Upon ER stress or specific stimuli, CREB3L4 undergoes regulated intramembrane proteolysis (RIP), releasing its N-terminal fragment, which translocates to the nucleus to regulate gene expression.
Functionally, CREB3L4 is implicated in lipid metabolism, inflammation, and cellular stress responses. It activates genes involved in lipid homeostasis, such as those in lipoprotein lipase pathways, and interacts with nuclear receptors like PPARα. Its expression is enriched in gastrointestinal tissues, liver, and certain endocrine organs, though reports on its tissue distribution vary. Dysregulation of CREB3L4 has been linked to metabolic disorders and cancers, including prostate and breast cancer, where it may promote tumor progression.
Antibodies targeting CREB3L4 are essential for investigating its expression patterns, activation mechanisms, and roles in disease. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding research into its physiological and pathological functions. Validation of these antibodies ensures specificity for distinguishing CREB3L4 from related family members (e.g., CREB3. CREB3L1-3), which share structural similarities but exhibit distinct regulatory roles.
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