| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hyaluronan and proteoglycan link protein 3, HAPLN3, EXLD1 |
| Entrez GeneID | 145864 |
| WB Predicted band size | 40.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HAPLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the Central region of human HAPLN3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于HAPLN3抗体的示例文献(内容为假设性概括，建议通过学术数据库验证具体文献)：
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1. **文献名称**: *HAPLN3 regulates extracellular matrix remodeling in osteoarthritis*
**作者**: Smith A, et al. (2023)
**摘要**: 研究利用兔源多克隆HAPLN3抗体，通过Western blot和免疫组化验证其在骨关节炎软骨组织中的表达升高，揭示HAPLN3通过稳定细胞外基质影响疾病进展。
2. **文献名称**: *HAPLN3 as a novel biomarker for ovarian cancer progression*
**作者**: Chen L, et al. (2021)
**摘要**: 开发小鼠单克隆HAPLN3抗体用于ELISA检测，发现卵巢癌患者血清HAPLN3水平与肿瘤转移相关，提示其作为预后生物标志物的潜力。
3. **文献名称**: *Antibody-mediated inhibition of HAPLN3 suppresses tumor angiogenesis*
**作者**: Tanaka K, et al. (2019)
**摘要**: 研究通过中和性HAPLN3抗体阻断其与透明质酸结合，证实其在体外和小鼠模型中抑制血管生成，为靶向治疗提供实验依据。
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**备注**：以上为模拟示例，实际文献需通过PubMed、Web of Science等平台以关键词“HAPLN3 antibody”或“HAPLN3 function”检索，并关注抗体开发、验证或应用的原始研究。
HAPLN3 (Hyaluronan and Proteoglycan Link Protein 3) is a member of the hyaluronan and proteoglycan link protein family, which plays a critical role in stabilizing extracellular matrix (ECM) structures by binding hyaluronan and proteoglycans. This interaction is essential for maintaining tissue integrity, particularly in cartilage and neural tissues, where ECM organization impacts mechanical resilience and cellular signaling. HAPLN3 is implicated in developmental processes, tissue homeostasis, and pathological conditions, including cancer and degenerative diseases. Dysregulation of HAPLN3 expression has been linked to tumor progression, where it may influence cell adhesion, migration, and microenvironment remodeling.
Antibodies targeting HAPLN3 are vital tools for studying its localization, expression patterns, and functional mechanisms. They enable detection in immunoassays (e.g., Western blot, immunohistochemistry) and facilitate research into its role in ECM dynamics, disease pathways, and potential therapeutic targeting. Recent studies explore HAPLN3's association with cancer metastasis and cartilage disorders, highlighting its dual role as both a structural component and a signaling modulator. However, its precise molecular interactions and tissue-specific functions remain under investigation, underscoring the need for high-specificity antibodies to advance mechanistic insights.
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