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Rabbit Polyclonal PANX3(N-term) Antibody

  • 中文名： PANX3 (N-term)抗体
  • 别    名： Pannexin-3, PANX3
货号: IPDX31677
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPannexin-3, PANX3
Entrez GeneID116337
WB Predicted band size44.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PANX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-31 amino acids from the N-terminal region of human PANX3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PANX3(N-terminal)抗体的示例参考文献(内容为模拟生成，建议通过学术数据库核实准确性)：

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1. **"Pannexin 3 regulates skeletal development through ATP release and ERK signaling"**

*作者：Penuela S. et al.*

**摘要**：研究揭示了PANX3在成骨细胞分化和骨骼矿化中的作用，通过N端特异性抗体(抗PANX3 N-term)进行免疫组化(IHC)和Western blot(WB)验证其在骨组织中的表达及功能。

2. **"PANX3 modulates epidermal differentiation through connexin-like channel activity"**

*作者：Bondarenko A. et al.*

**摘要**：利用抗PANX3 N-term抗体探究其在皮肤角质细胞分化中的表达模式，发现PANX3通过ATP信号通路调控表皮屏障功能，抗体用于免疫荧光(IF)和流式细胞术验证。

3. **"Pannexin 3 deficiency alters extracellular matrix composition in dental mineralization"**

*作者：Lacruz R.S. et al.*

**摘要**：研究PANX3在牙齿发育中的功能，通过N端抗体检测其在成牙本质细胞中的定位，证实其通过调节钙离子通量影响矿化过程。

4. **"Role of PANX3 in retinal pigment epithelial cell apoptosis"**

*作者：Dvoriantchikova G. et al.*

**摘要**：采用抗PANX3 N-term抗体研究其在视网膜退行性疾病中的作用，发现PANX3通过激活炎症信号通路促进细胞凋亡，抗体用于WB和免疫沉淀(IP)实验。

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**注意**：以上文献为示例，实际文献需通过PubMed、Web of Science等平台检索确认。建议结合抗体生产商(如Abcam、Santa Cruz等)提供的产品引用文献进一步验证。

背景信息

The PANX3 (N-term) antibody is a tool designed to target the N-terminal region of Pannexin 3 (PANX3), a member of the pannexin family of transmembrane channel-forming proteins. Pannexins, including PANX1. PANX2. and PANX3. are involved in intercellular communication, facilitating the transport of small molecules like ATP and metabolites. PANX3 is predominantly expressed in skin, bone, and cartilage tissues, where it regulates processes such as cell differentiation, apoptosis, and extracellular matrix remodeling. Its N-terminal domain plays a critical role in channel gating and protein-protein interactions. The PANX3 (N-term) antibody is commonly used in research to detect and study PANX3 expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It has been instrumental in elucidating PANX3’s role in skeletal development, skin homeostasis, and pathologies like osteoarthritis or cancer metastasis. Validated for specificity, this antibody typically detects a band around 40-45 kDa (unmodified PANX3) in immunoblot assays. Its development has supported investigations into PANX3’s dual roles as a channel protein and a signaling modulator, particularly in tissues with high mechanical stress or rapid turnover. Researchers rely on this antibody to explore therapeutic targets linked to PANX3 dysregulation in metabolic disorders or degenerative diseases.

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