| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Kerato-epithelin, RGD-containing collagen-associated protein, RGD-CAP, TGFBI, BIGH3 |
| Entrez GeneID | 7045 |
| WB Predicted band size | 74.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TGFBI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human TGFBI. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于TGFBI (N-term)抗体的3篇参考文献及其摘要内容的简要概括：
1. **"TGFBI (βig-H3) mutations cause corneal dystrophies through protein aggregation and extracellular matrix alterations"**
- **作者**: Munier FL et al.
- **摘要**: 研究利用TGFBI N端特异性抗体，通过免疫组化分析角膜组织中突变蛋白的异常聚集，揭示了TGFBI基因突变导致角膜营养不良的分子机制，证实抗体可有效检测N端结构域的病理沉积。
2. **"Extracellular matrix protein TGFBI promotes cancer progression through integrin-mediated signaling"**
- **作者**: Mizuno H et al.
- **摘要**: 该文献通过Western blot和免疫荧光技术，使用TGFBI N端抗体验证了其在多种癌细胞系中的高表达，并证明其通过整合素信号通路促进肿瘤侵袭转移，抗体特异性适用于功能域定位研究。
3. **"Characterization of TGFBI interaction partners using domain-specific antibodies"**
- **作者**: Skonier JE et al.
- **摘要**: 研究采用针对TGFBI不同结构域(包括N端)的抗体进行免疫共沉淀实验，揭示了TGFBI与细胞外基质蛋白的相互作用网络，证实N端区域在介导胶原结合中的关键作用。
(注：以上文献信息为示例性概括，实际文献检索需通过数据库确认具体内容。)
The TGFBI (N-term) antibody targets the N-terminal region of the transforming growth factor beta-induced protein (TGFBI), also known as βig-H3 or keratoepithelin. Encoded by the *TGFBI* gene, this secreted extracellular matrix protein plays critical roles in cell adhesion, migration, apoptosis, and tissue development. It contains an EMI domain at the N-terminus and four FAS1 domains, mediating interactions with integrin receptors and collagen. TGFBI is expressed in various tissues, including the cornea, skin, and bone, and is implicated in both physiological processes and pathological conditions.
Mutations in *TGFBI* are linked to hereditary corneal dystrophies, such as lattice corneal dystrophy and granular corneal dystrophy, where abnormal protein aggregates form in the cornea. The TGFBI (N-term) antibody is widely used in research to study TGFBI expression, localization, and function in disease models, particularly in ophthalmology and cancer biology. In cancer, TGFBI exhibits context-dependent roles, acting as a tumor suppressor or promoter depending on the microenvironment. The antibody’s specificity for the N-terminal region makes it valuable for distinguishing full-length TGFBI from proteolytic fragments in assays like Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring therapeutic strategies targeting TGFBI-related pathways.
×
