| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 436, ZNF436, KIAA1710 |
| Entrez GeneID | 80818 |
| WB Predicted band size | 54.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF436 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human ZNF436. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF436 (N-term)抗体的3篇参考文献示例(注：以下内容为虚构示例，实际文献需通过学术数据库查询)：
1. **"ZNF436 N-terminal antibody characterization in transcriptional regulation studies"**
*作者：Smith A, et al.*
摘要：本研究验证了ZNF436 (N-term)抗体在Western blot和免疫荧光中的特异性，证实其能识别人类细胞核中的ZNF436蛋白，并用于探究其在DNA损伤应答中的转录调控作用。
2. **"Role of ZNF436 in neuronal differentiation revealed by N-terminal epitope targeting"**
*作者：Li Y, et al.*
摘要：通过使用ZNF436 (N-term)抗体，研究者发现ZNF436在小鼠脑发育中高表达，并通过ChIP实验证明其与神经分化相关基因启动子区域的结合。
3. **"ZNF436 interacts with p53: Evidence from co-immunoprecipitation using N-terminal specific antibodies"**
*作者：Chen H, et al.*
摘要：该文献利用ZNF436 (N-term)抗体进行免疫共沉淀实验，揭示了ZNF436与肿瘤抑制蛋白p53的相互作用，提示其在癌症发生中的潜在调控机制。
建议通过PubMed或Google Scholar以“ZNF436 antibody N-terminal”为关键词检索真实文献。
The ZNF436 (N-term) antibody is designed to target the N-terminal region of the Zinc Finger Protein 436 (ZNF436), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins are characterized by tandem C2H2-type zinc finger motifs, which facilitate DNA binding, and a KRAB domain that often mediates transcriptional repression through interactions with co-repressors. ZNF436 is implicated in regulating gene expression, particularly in developmental processes, cellular differentiation, and stress responses. Studies suggest it may act as a transcriptional repressor, influencing pathways related to apoptosis, immune regulation, and cancer progression.
The N-terminal-specific antibody allows researchers to distinguish ZNF436 from structurally similar proteins, enabling precise detection in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). It is commonly used to study ZNF436's expression patterns, subcellular localization (primarily nuclear), and interactions with partner proteins or DNA targets. Validation typically includes testing in knockout cell lines or tissues to confirm specificity. Dysregulation of ZNF436 has been observed in certain cancers and neurological disorders, making this antibody a valuable tool for exploring its functional roles in disease mechanisms and potential therapeutic applications.
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