| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cysteine-rich protein 2, CRP-2, Protein ESP1, CRIP2, CRP2 |
| Entrez GeneID | 1397 |
| WB Predicted band size | 22.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-208 amino acids from the C-terminal region of human CRIP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及CRIP2抗体的参考文献摘要信息，供参考：
1. **文献名称**: "CRIP2 suppresses prostate cancer growth by regulating cell cycle and apoptosis"
**作者**: Li Y, et al.
**摘要**: 研究利用CRIP2抗体进行Western blot和免疫组化，发现CRIP2通过抑制cyclin D1和激活caspase-3通路，抑制前列腺癌细胞增殖并诱导凋亡。
2. **文献名称**: "Cysteine-rich intestinal protein 2 (CRIP2) as a prognostic biomarker in non-small cell lung cancer"
**作者**: Wang X, et al.
**摘要**: 通过CRIP2抗体免疫染色分析肺癌组织样本，发现CRIP2低表达与患者生存期缩短相关，提示其可能作为肺癌预后标志物。
3. **文献名称**: "CRIP2 modulates vascular smooth muscle cell phenotype via Wnt/β-catenin signaling"
**作者**: Chen L, et al.
**摘要**: 研究使用CRIP2抗体进行免疫共沉淀实验，发现CRIP2通过与β-catenin互作调控血管平滑肌细胞表型转化，影响动脉粥样硬化进程。
注：以上文献为示例性内容，实际引用时建议通过PubMed或Google Scholar核实具体文献信息及抗体应用细节。
CRIP2 (Cysteine-Rich Protein 2), also known as CRP2. is a member of the LIM domain protein family, characterized by zinc-binding motifs critical for protein-protein interactions. Initially identified in smooth muscle cells, CRIP2 is involved in regulating cytoskeletal organization, cell differentiation, and transcriptional regulation. It interacts with components of the actin cytoskeleton and transcription factors, playing roles in muscle development, cardiovascular function, and neural processes. Dysregulation of CRIP2 has been linked to diseases such as cancer, where it may act as a tumor suppressor or promoter depending on context, and cardiovascular disorders.
CRIP2 antibodies are essential tools for studying its expression, localization, and function. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into tissue-specific expression patterns and disease mechanisms. Commercial CRIP2 antibodies are typically raised in rabbits or mice, targeting specific epitopes within its LIM domains or unique regions. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity. Recent studies explore CRIP2's potential as a biomarker in cancers or its role in cardiomyocyte repair, highlighting its therapeutic relevance. However, inconsistencies in reported functions underscore the need for further research to clarify its dual roles in different pathological contexts.
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