| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dyrk1b |
| Entrez GeneID | 13549 |
| WB Predicted band size | 69.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Dyrk1b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-403 amino acids from the Central region of mouse Dyrk1b. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse DYRK1B抗体的示例参考文献(部分为模拟构造，实际引用时请核实数据库)：
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1. **"Characterization of a Novel Monoclonal Antibody Against Mouse DYRK1B for Immunoblotting Applications"**
*作者：Smith A, et al. (2018)*
*摘要*：本研究开发了一种针对小鼠DYRK1B蛋白的单克隆抗体，并通过Western blot和免疫组化验证其特异性。实验表明该抗体能特异性识别小鼠组织中的DYRK1B，且无交叉反应性，适用于细胞周期相关研究。
2. **"DYRK1B Regulates Adipogenesis via mTORC1 Signaling: Insights from Antibody-Based Knockdown Studies"**
*作者：Chen L, et al. (2020)*
*摘要*：利用小鼠DYRK1B抗体探究其在脂肪生成中的作用。研究发现DYRK1B通过调控mTORC1通路抑制脂肪细胞分化，抗体染色结果显示其在脂肪前体细胞中高表达。
3. **"Overexpression of DYRK1B in Pancreatic Cancer: A Study Using Mouse-Specific Antibodies"**
*作者：Johnson R, et al. (2019)*
*摘要*：通过免疫荧光和流式细胞术分析DYRK1B在小鼠胰腺癌模型中的表达。结果显示DYRK1B在肿瘤组织中显著上调，提示其可能作为潜在治疗靶点。
4. **"Development of a Phospho-Specific Antibody for Mouse DYRK1B to Study Kinase Activity in vivo"**
*作者：Wang Y, et al. (2021)*
*摘要*：报道了一种针对小鼠DYRK1B磷酸化位点的抗体，用于检测其激酶活性。实验证明该抗体可特异性识别激活状态下的DYRK1B，适用于信号通路动态分析。
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**注意**：以上文献信息为示例性质，实际引用请通过PubMed、Google Scholar等平台检索关键词(如“DYRK1B antibody mouse”或“DYRK1B murine”)获取真实研究。
The mouse DYRK1B antibody is a specialized tool used to detect and study the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) protein in murine models. DYRK1B, a member of the DYRK kinase family, plays critical roles in cellular processes such as cell cycle regulation, differentiation, and metabolic homeostasis. It is structurally related to DYRK1A, sharing a conserved kinase domain, but exhibits distinct tissue-specific expression patterns and functions. Dysregulation of DYRK1B has been implicated in diseases including cancer, obesity, and diabetes, making it a target for therapeutic research.
Mouse-specific DYRK1B antibodies are typically developed using immunogenic peptides or recombinant proteins from the murine DYRK1B sequence. These antibodies enable researchers to investigate protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Validation often includes testing on DYRK1B knockout models or cell lines to confirm specificity.
Such antibodies are vital in preclinical studies using mouse models to explore DYRK1B's role in tumor progression (e.g., pancreatic and ovarian cancers) and metabolic disorders. They also aid in evaluating DYRK1B inhibitors or genetic manipulation strategies. Researchers prioritize antibodies with high affinity, minimal cross-reactivity (e.g., with DYRK1A), and compatibility with multiple experimental platforms to ensure robust, reproducible results in complex biological systems.
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