| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 395, HD-regulating factor 2, HDRF-2, Huntington disease gene regulatory region-binding protein 2, HD gene regulatory region-binding protein 2, HDBP-2, Papillomavirus regulatory factor 1, PRF-1, Papillomavirus-binding factor, ZNF395, HDBP2, PBF |
| Entrez GeneID | 55893 |
| WB Predicted band size | 54.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF395 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-322 amino acids from the Central region of human ZNF395. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ZNF395抗体相关的文献示例(注：文献信息为模拟示例，实际引用需核实原文)：
1. **文献名称**: "ZNF395 as a hypoxia-regulated mediator in melanoma cell adaptation to low oxygen conditions"
**作者**: Schmidt, M. et al.
**摘要**: 研究揭示了ZNF395在缺氧条件下通过调控VEGF和HIF-1α通路促进黑色素瘤细胞存活的作用，使用ZNF395抗体进行Western blot和免疫组化验证其表达上调。
2. **文献名称**: "The role of ZNF395 in the regulation of inflammatory response in glioblastoma"
**作者**: Smith, J.R. & Wang, L.
**摘要**: 通过ZNF395抗体阻断实验，证明ZNF395通过NF-κB通路增强胶质母细胞瘤的炎症反应，提示其作为潜在治疗靶点。
3. **文献名称**: "Antibody-based profiling of ZNF395 in neurodevelopmental disorders"
**作者**: Chen, H. et al.
**摘要**: 开发并验证了一种高特异性ZNF395单克隆抗体，用于检测自闭症患者脑组织中ZNF395的异常表达及其与突触功能异常的关联。
如需真实文献，建议在PubMed或Web of Science检索关键词：**ZNF395 antibody**、**ZNF395 function**、**ZNF395 expression analysis**。
The ZNF395 antibody is a tool used to detect the zinc finger protein 395 (ZNF395), a transcription factor encoded by the *ZNF395* gene. ZNF395 contains a Krüppel-associated box (KRAB) domain and multiple C2H2 zinc finger motifs, which enable its role in DNA binding and transcriptional regulation. This protein is implicated in cellular stress responses, particularly under hypoxia, where it interacts with hypoxia-inducible factor 1-alpha (HIF-1α) to modulate gene expression. ZNF395 is also linked to pathways involving p53. NF-κB, and interferon signaling, suggesting dual roles in apoptosis and survival depending on cellular context.
Research highlights its involvement in cancer biology, especially in sarcomas and hepatocellular carcinoma, where it may act as an oncogene or tumor suppressor. Additionally, ZNF395 is associated with neurodegenerative disorders like Huntington’s disease, regulating stress-responsive genes in neuronal cells. The antibody is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP) to study ZNF395’s expression, localization, and molecular interactions. Its application aids in exploring mechanisms underlying tumor progression, hypoxia adaptation, and neuroprotection, making it valuable for both basic research and translational studies targeting ZNF395-related pathways.
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