| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dual specificity protein kinase CLK1, CDC-like kinase 1, Protein kinase STY, Clk1, Clk, Sty |
| Entrez GeneID | 12747 |
| WB Predicted band size | 57.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Clk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the N-terminal region of mouse Clk1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠CLK1 (N-term)抗体的参考文献示例(注：部分文献可能为模拟概括，建议通过数据库核实)：
1. **文献名称**：*Characterization of CLK1 Kinase Activity in Mouse Embryonic Development*
**作者**：Smith A, et al.
**摘要**：本研究利用针对小鼠CLK1 N端的特异性抗体，通过免疫沉淀和Western blot分析，揭示了CLK1在小鼠胚胎干细胞分化过程中的动态表达及激酶活性调控机制。
2. **文献名称**：*CLK1-Mediated RNA Splicing in Neuronal Differentiation*
**作者**：Chen L, et al.
**摘要**：作者使用CLK1 (N-term)抗体进行免疫荧光和亚细胞定位实验，证明CLK1在神经元分化过程中通过调控前体mRNA剪接影响突触相关基因的表达。
3. **文献名称**：*A Novel Role of CLK1 in Mitochondrial Function*
**作者**：Yamamoto K, et al.
**摘要**：该研究通过CLK1 N端抗体的Western blot验证基因敲除小鼠模型，发现CLK1缺失导致线粒体代谢异常，提示其参与能量稳态调控。
4. **文献名称**：*Antibody Validation for CLK1 Isoform-Specific Studies*
**作者**：Park J, et al.
**摘要**：文章系统评估了多种CLK1抗体(包括N端抗体)的特异性，确认其在区分CLK1与其他CDC-like激酶家族成员中的应用价值。
**注意**：以上文献为示例性质，实际引用时需通过PubMed、Google Scholar等平台以“CLK1 antibody”“mouse CLK1 N-terminal”等关键词检索真实文献，并关注抗体生产商(如CST、Abcam)产品页引用的参考文献。
The Mouse Clk1 (N-term) antibody is a specific immunological tool designed to detect the N-terminal region of the CDC-like kinase 1 (Clk1) protein in mouse-derived samples. Clk1. a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, plays critical roles in regulating RNA splicing, cellular signaling, and stress responses by phosphorylating serine/arginine-rich (SR) proteins involved in pre-mRNA processing. This kinase is implicated in diverse biological processes, including cell cycle progression, differentiation, and apoptosis, with dysregulation linked to diseases such as cancer and neurodegenerative disorders.
The antibody is typically produced by immunizing hosts with a synthetic peptide or recombinant protein corresponding to the N-terminal region of mouse Clk1. ensuring specificity for this epitope. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study Clk1 expression, localization, and post-translational modifications in tissues or cell lines. Researchers employ this antibody to investigate Clk1's functional interactions in splicing regulation, its response to cellular stressors, and its potential as a therapeutic target. Validation often includes knockout controls or siRNA-mediated silencing to confirm binding specificity. As Clk1 homologs are conserved across species, findings in mouse models using this antibody may provide insights into human disease mechanisms.
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