| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH287801} |
| Entrez GeneID | 269275 |
| WB Predicted band size | 54.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of mouse Acvr1c. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠Acvr1c抗体的3篇参考文献，按您的要求整理：
1. **"Characterization of Acvr1c Antibody Specificity in Mouse Tissues"**
- 作者：Li, X. et al.
- 摘要：该研究通过免疫组化和Western blot验证了小鼠Acvr1c抗体的特异性，发现其在睾丸和大脑中高表达，并确认抗体可用于检测Acvr1c蛋白的定位及表达水平变化。
2. **"Acvr1c Signaling in Metabolic Regulation: Insights from Antibody-Based Knockdown Models"**
- 作者：Saito, K. & Watanabe, H.
- 摘要：利用Acvr1c抗体在小鼠模型中靶向抑制受体活性，揭示Acvr1c通过调控脂代谢通路影响能量平衡，为肥胖相关研究提供工具支持。
3. **"Developmental Expression Profiling of Acvr1c in Mouse Embryos Using a Novel Monoclonal Antibody"**
- 作者：Gupta, R. et al.
- 摘要：开发了一种高特异性抗小鼠Acvr1c单克隆抗体，系统分析了胚胎发育阶段Acvr1c的动态表达模式，证实其在神经管和肢芽形成中的关键作用。
注：以上文献为模拟示例，实际研究中建议通过PubMed或Google Scholar以关键词“Acvr1c antibody mouse”检索最新文章。若需具体文献，请提供更详细的研究方向或PMID编号。
The mouse ACVR1C antibody is a crucial tool for studying the Activin A receptor type 1C (ACVR1C), a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. ACVR1C, also known as ALK7. plays a pivotal role in mediating signaling pathways activated by ligands such as Activins, Nodal, and Growth Differentiation Factors (GDFs). These pathways regulate diverse biological processes, including cellular differentiation, metabolism, and apoptosis. In mice, ACVR1C is particularly implicated in metabolic homeostasis, pancreatic function, and adipose tissue regulation, with links to obesity and diabetes research.
The antibody specifically targets the mouse ACVR1C protein, enabling detection and quantification in various experimental setups like Western blotting, immunohistochemistry, and flow cytometry. It is often generated in hosts such as rabbits or mice, with validation steps confirming specificity through knockout controls or siRNA knockdown. Researchers use this antibody to explore ACVR1C's expression patterns, post-translational modifications, and interactions within signaling cascades. Its applications extend to disease models, particularly metabolic disorders and cancer, where ACVR1C dysregulation is observed. Reliable antibodies are essential for elucidating ACVR1C's tissue-specific roles and therapeutic potential.
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