| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7 |
| Entrez GeneID | 122809 |
| WB Predicted band size | 50.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SOCS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-253 amino acids from the Central region of human SOCS4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SOCS4抗体的3篇模拟参考文献示例(基于领域常见研究方向的合理推断，非真实文献)：
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1. **标题**: *SOCS4 suppresses tumor growth via EGFR degradation in triple-negative breast cancer*
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化(使用兔源SOCS4抗体)发现，SOCS4通过促进EGFR泛素化降解抑制三阴性乳腺癌增殖，其低表达与患者不良预后相关。
2. **标题**: *Development of a high-affinity monoclonal SOCS4 antibody for functional proteomics*
**作者**: Tanaka K, et al.
**摘要**: 团队开发了小鼠单克隆SOCS4抗体，验证其在ELISA、Western blot及免疫共沉淀中的特异性，并用于筛选与SOCS4相互作用的STAT3通路蛋白。
3. **标题**: *SOCS4 modulates T-cell inflammation through JAK1 regulation: Insights from knockout models*
**作者**: Müller R, et al.
**摘要**: 利用SOCS4抗体进行流式细胞术和共聚焦成像，发现SOCS4缺陷T细胞中JAK1磷酸化增强，导致过度炎症反应，提示其在自身免疫病中的调控作用。
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**说明**：以上为模拟内容，实际文献需通过PubMed或Google Scholar检索关键词(如“SOCS4 antibody application”“SOCS4 signaling”)获取。如需具体文献，建议补充研究背景(如疾病方向或实验用途)。
The SOCS4 (Suppressor of Cytokine Signaling 4) antibody is a research tool designed to detect and study the SOCS4 protein, a member of the SOCS family involved in regulating cytokine signaling pathways. SOCS proteins act as negative feedback inhibitors of the JAK-STAT pathway, which mediates cellular responses to cytokines and growth factors. SOCS4. specifically, is implicated in modulating immune responses, cell proliferation, and differentiation by targeting signaling components for degradation via the ubiquitin-proteasome system. Its role in diseases like cancer, autoimmune disorders, and metabolic conditions is under investigation, though it remains less characterized compared to other SOCS members (e.g., SOCS1 or SOCS3).
The SOCS4 antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in cell or tissue samples. Validation typically includes testing in SOCS4 knockout models or siRNA-treated cells to confirm specificity. Researchers utilize this antibody to explore SOCS4's regulatory mechanisms in physiological and pathological contexts, aiming to clarify its therapeutic potential. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal) vary, impacting experimental applications. Reliable SOCS4 antibodies are critical for advancing studies on cytokine signaling dysregulation and related diseases.
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