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Rabbit Polyclonal SEMG1(N-term) Antibody

  • 中文名: SEMG1 (N-term)抗体
  • 别    名: Semenogelin-1, Semenogelin I, SGI, Alpha-inhibin-92, Alpha-inhibin-31, Seminal basic protein, SEMG1, SEMG
货号: IPDX31490
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSemenogelin-1, Semenogelin I, SGI, Alpha-inhibin-92, Alpha-inhibin-31, Seminal basic protein, SEMG1, SEMG
Entrez GeneID6406
WB Predicted band size52.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SEMG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the N-terminal region of human SEMG1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SEMG1 (N-term)抗体的参考文献示例(内容为虚构,仅作格式参考):

1. **"Characterization of a novel monoclonal antibody against the N-terminal region of SEMG1"**

- **作者**: Smith A, et al.

- **摘要**: 本研究开发了一种针对SEMG1蛋白N端表位的单克隆抗体,通过免疫印迹和免疫组化验证其特异性,证实其在精液样本中检测SEMG1的应用潜力,为生殖系统疾病诊断提供工具。

2. **"SEMG1 N-terminal epitope mapping and its role in semen coagulation"**

- **作者**: Chen L, et al.

- **摘要**: 通过抗原表位定位分析,确定SEMG1 N端的关键功能域,并利用特异性抗体揭示该区域在精液凝固过程中的分子机制,为男性不育研究提供新见解。

3. **"Development of polyclonal antibodies targeting SEMG1 for forensic identification"**

- **作者**: Kim H, et al.

- **摘要**: 报道一种针对SEMG1 N端的高效多克隆抗体制备方法,验证其在法医学精斑鉴定中的灵敏度和特异性,证明其在低浓度样本中的可靠检测能力。

4. **"SEMG1 as a biomarker in prostate cancer: Validation of an N-terminal antibody-based assay"**

- **作者**: Gonzalez R, et al.

- **摘要**: 评估SEMG1 N端抗体在血清检测中的性能,发现其在前列腺癌患者中表达显著升高,提示其作为肿瘤标志物的潜在临床价值。

(注:以上文献为模拟示例,实际引用需查询PubMed、Google Scholar等数据库获取真实文献。)

背景信息

The SEMG1 (N-term) antibody targets the N-terminal region of Semenogelin-1 (SEMG1), a key protein in seminal fluid predominantly secreted by the seminal vesicles. SEMG1 is a major component of the semen coagulum, forming a gel-like matrix that entraps sperm after ejaculation. This protein plays a critical role in sperm motility regulation, lubrication, and protection against pathogens. Structurally, SEMG1 contains multiple glutamine- and cysteine-rich domains, with the N-terminal region involved in cross-linking interactions with SEMG2 (its paralog) during coagulation. The SEMG1 (N-term) antibody is widely used in reproductive biology and clinical research to study SEMG1 expression, localization, and function. It aids in detecting SEMG1 in biological samples via techniques like Western blotting, immunohistochemistry (IHC), and ELISA. Aberrant SEMG1 levels or mutations have been linked to male infertility, impaired semen coagulation, and pathological conditions such as prostate cancer. Additionally, SEMG1 has been explored as a biomarker in forensic analysis for semen identification. Research using this antibody contributes to understanding seminal protein dynamics, sperm physiology, and reproductive disorders, highlighting its importance in both basic and applied biomedical studies.

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