| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512 |
| Entrez GeneID | 5798 |
| WB Predicted band size | 105.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PTPRN抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"Cloning and characterization of IA-2. a transmembrane protein tyrosine phosphatase related to autoantigens in insulin-dependent diabetes"*
**作者**：Rabin, D.U. 等(1994)
**摘要内容**：该研究首次克隆并鉴定了PTPRN(原名IA-2)的基因，发现其编码一种跨膜酪氨酸磷酸酶，是1型糖尿病中胰岛细胞自身抗体的主要靶点之一，揭示了其与胰岛β细胞自身免疫破坏的关联。
2. **文献名称**：*"Autoantibodies to the tyrosine phosphatase PTPRN are broadly associated with neuroendocrine tumors and may be linked to disease progression"*
**作者**：Lan, M.S. 等(2016)
**摘要内容**：研究发现PTPRN抗体在神经内分泌肿瘤(如胰岛细胞瘤、小细胞肺癌)患者血清中显著升高，提示其可能作为诊断标志物，并可能与肿瘤的侵袭性和转移相关。
3. **文献名称**：*"PTPRN autoantibodies in type 1 diabetes: epitope mapping and prognostic significance"*
**作者**：Kawasaki, E. 等(2003)
**摘要内容**：该研究通过分析1型糖尿病患者血清，发现PTPRN抗体的存在与疾病早期发病及快速β细胞功能丧失相关，并通过表位定位揭示了其与疾病进展的潜在机制。
(注：以上文献信息为示例性质，具体内容需以实际文献为准。)
PTPRN (Protein Tyrosine Phosphatase Receptor Type N), also known as IA-2 (Islet Antigen-2), is a transmembrane protein belonging to the receptor-type protein tyrosine phosphatase (PTP) family. It is predominantly expressed in neuroendocrine tissues, including pancreatic islet β-cells, brain, and adrenal glands. The PTPRN gene encodes a protein with an extracellular domain, a transmembrane region, and an intracellular phosphatase domain. While its precise physiological role remains under investigation, PTPRN is implicated in regulating secretory granule dynamics and hormone release, particularly insulin secretion in pancreatic β-cells.
Antibodies targeting PTPRN are primarily studied in two contexts. First, autoantibodies against PTPRN/IA-2 are well-established biomarkers in type 1 diabetes (T1D) research. Their presence in serum is a diagnostic and predictive indicator of autoimmune-driven β-cell destruction, often appearing years before clinical onset. Second, research-grade PTPRN antibodies (monoclonal or polyclonal) are tools for investigating the protein's expression, localization, and function in cellular models. These antibodies are utilized in techniques like immunohistochemistry, Western blotting, and immunofluorescence to study neuroendocrine tumors, neurological disorders, and diabetes pathogenesis. Recent studies also explore PTPRN's potential role in cancer progression and neuronal signaling. However, the enzymatic activity of its intracellular domain remains paradoxical, as key catalytic residues are mutated, suggesting non-enzymatic regulatory functions. This duality makes PTPRN antibodies critical for unraveling its complex biology.
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