| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 1 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-I, IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD1 |
| Entrez GeneID | 3614 |
| WB Predicted band size | 55.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IMPDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-514 amino acids from the C-terminal region of human IMPDH1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于IMPDH1抗体的代表性文献摘要(人工整理，非真实文献，仅供示例参考)：
1. **文献名称**：*IMPDH1-specific monoclonal antibody development and its application in cancer biomarker screening*
**作者**：Smith A, et al. (2018)
**摘要**：本研究开发了一种高特异性的IMPDH1单克隆抗体，验证其在Western blot和免疫组化中的敏感性，发现IMPDH1在结直肠癌组织中显著高表达，提示其作为肿瘤代谢标志物的潜力。
2. **文献名称**：*IMPDH1 antibody reveals its nucleolar localization and association with ribosome biogenesis*
**作者**：Chen L, et al. (2015)
**摘要**：通过IMPDH1抗体的免疫荧光染色，首次证明IMPDH1在细胞核仁中的定位，并发现其与核糖体RNA合成通路相关，为IMPDH1调控细胞增殖机制提供新视角。
3. **文献名称**：*Validation of IMPDH1 antibody for detecting retinal degeneration-related mutations*
**作者**：Wang Y, et al. (2020)
**摘要**：验证商用IMPDH1抗体在患者视网膜组织中的特异性，发现特定突变导致IMPDH1蛋白稳定性下降，为遗传性视网膜病变的分子诊断提供工具。
4. **文献名称**：*IMPDH1 inhibition and antibody-based functional analysis in autoimmune diseases*
**作者**：Kim J, et al. (2021)
**摘要**：利用IMPDH1抗体研究抑制剂对B细胞活化的影响，揭示IMPDH1通过调控GTP合成参与系统性红斑狼疮的免疫异常通路。
(注：以上为虚拟示例，实际文献需通过PubMed或Google Scholar以关键词"IMPDH1 antibody"检索。)
IMPDH1 (Inosine-5'-monophosphate dehydrogenase type 1) is a rate-limiting enzyme in the de novo biosynthesis of guanine nucleotides, catalyzing the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP). This enzyme plays a critical role in cellular proliferation, immune function, and metabolism, making it a target for immunosuppressive and anticancer therapies. IMPDH1 is highly expressed in rapidly dividing cells, including activated lymphocytes and certain cancer cells, and its activity is linked to diseases such as retinopathy, viral infections, and hematologic malignancies.
IMPDH1 antibodies are essential tools for studying the expression, localization, and function of this enzyme in research and diagnostics. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect IMPDH1 in various biological samples. Monoclonal and polyclonal antibodies against IMPDH1 are available, often validated for specificity using knockout controls or siRNA-mediated knockdown. Some antibodies distinguish IMPDH1 from its isoform IMPDH2. which shares ~84% amino acid sequence homology but differs in tissue distribution and regulatory mechanisms.
Research applications include investigating IMPDH1's role in cell cycle regulation, nucleotide metabolism, and responses to therapeutic agents like mycophenolic acid (MPA), a selective IMPDH inhibitor used in organ transplantation. Dysregulation of IMPDH1 has also been implicated in autosomal dominant retinitis pigmentosa (adRP), making its antibodies valuable for studying neurodegenerative eye diseases. Commercial IMPDH1 antibodies typically react with human, mouse, and rat samples, aiding cross-species comparative studies.
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