| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UDP-glucuronosyltransferase 2B11, UDPGT 2B11, UGT2B11 |
| Entrez GeneID | 10720 |
| WB Predicted band size | 61.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This UGT2B11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the C-terminal region of human UGT2B11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于UGT2B11抗体的3篇示例参考文献(注：以下为模拟文献，实际文献需通过学术数据库检索确认)：
1. **标题**: "Characterization of UGT2B11 Expression in Human Liver Using a Novel Polyclonal Antibody"
**作者**: Smith, J.R., et al.
**摘要**: 本研究开发了一种特异性识别UGT2B11的多克隆抗体，通过免疫印迹和免疫组化验证其在人肝组织中的表达，发现UGT2B11在肝细胞中广泛分布，与药物代谢功能相关。
2. **标题**: "UGT2B11 Genetic Variants and Androgen Glucuronidation: Role in Prostate Cancer Progression"
**作者**: Lee, H., et al.
**摘要**: 利用UGT2B11抗体检测前列腺癌细胞系中蛋白表达水平，发现UGT2B11通过调节雄激素代谢影响癌细胞增殖，抗体特异性通过siRNA敲降实验验证。
3. **标题**: "Development of a Monoclonal Antibody for Quantification of UGT2B11 in Renal Tissues"
**作者**: Garcia, M., et al.
**摘要**: 报道了一种高灵敏度单克隆抗体的开发，用于定量肾脏组织中UGT2B11的表达，揭示其在肾脏药物清除中的潜在作用，抗体特异性通过质谱分析确认。
建议通过 **PubMed** 或 **Web of Science** 检索最新文献，关键词：**UGT2B11 antibody**。
The UGT2B11 antibody is a research tool designed to detect and study the UDP-glucuronosyltransferase 2B11 (UGT2B11) enzyme, a member of the UGT enzyme family involved in phase II metabolism. UGT2B11 catalyzes the glucuronidation of endogenous compounds (e.g., steroids, bile acids) and xenobiotics (e.g., drugs, toxins), enhancing their water solubility for excretion. It is expressed in tissues such as the liver, kidney, and gastrointestinal tract, with roles in hormone regulation, detoxification, and drug metabolism. Dysregulation of UGT2B11 has been linked to metabolic disorders, hormone-dependent cancers (e.g., prostate cancer), and interindividual variability in drug responses.
UGT2B11 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable the detection of UGT2B11 expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated antibodies are critical for studying UGT2B11's tissue-specific activity, genetic polymorphisms, and involvement in diseases or drug interactions. Researchers also use these antibodies to explore UGT2B11's role in metabolic pathways, potential biomarkers for disease prognosis, or therapeutic targets. Specificity and cross-reactivity with other UGT2B isoforms (e.g., UGT2B10. UGT2B17) must be rigorously tested to ensure reliable results.
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