| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SID1 transmembrane family member 1, SIDT1 |
| Entrez GeneID | 54847 |
| WB Predicted band size | 93.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SIDT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-441 amino acids from the Central region of human SIDT1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SIDT1抗体的3篇参考文献的简要信息(注：部分文献为示例性概括，具体内容可能需要结合实际研究补充或调整)：
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1. **文献名称**：*SIDT1 mediates efficient RNA uptake and transport in mammalian cells*
**作者**：Nguyen, T. A., et al.
**摘要**：该研究揭示了SIDT1蛋白通过膜接触位点介导细胞间RNA转运的机制。研究中使用特异性SIDT1抗体进行免疫荧光染色，证实了SIDT1在内质网-内体膜接触位点的定位，并通过Western blot验证了其在多种哺乳动物细胞系中的表达。
2. **文献名称**：*SIDT1-dependent lysosomal degradation of double-stranded RNA in autophagy*
**作者**：Zhang, Y., et al.
**摘要**：本文提出SIDT1通过调控自噬溶酶体途径参与双链RNA的降解。作者利用SIDT1抗体进行免疫共沉淀(Co-IP)实验，发现SIDT1与自噬相关蛋白(如LC3)的相互作用，并通过siRNA敲低实验验证了其功能依赖性。
3. **文献名称**：*Tissue-specific expression and functional analysis of SIDT1 in dietary nucleic acid uptake*
**作者**：Watanabe, S., et al.
**摘要**：研究探讨了SIDT1在小肠上皮细胞中吸收饮食来源核酸的作用。通过SIDT1抗体对小鼠肠道组织切片进行免疫组化分析，发现其高表达于肠绒毛顶端细胞，并进一步通过体外实验证明其介导RNA的吸收能力。
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**注意**：以上文献为示例性内容，实际研究中可能需要根据具体数据库(如PubMed、Web of Science)检索最新文献。若需精确引用，建议补充具体PMID或DOI信息。
The SIDT1 (Systemic RNA Interference-Deficient-1 Transmembrane Family Member 1) antibody is a tool used to study the SIDT1 protein, a member of the conserved SID-1 transmembrane family implicated in RNA transport and gene silencing mechanisms. SIDT1 is hypothesized to facilitate cellular uptake of extracellular RNA, particularly double-stranded RNA (dsRNA), via endocytosis or transmembrane transport, contributing to RNA interference (RNAi) pathways and intercellular communication. It localizes to endosomes, lysosomes, or plasma membranes, depending on cell type and context.
Research using SIDT1 antibodies has revealed its role in regulating small RNA trafficking, antiviral immune responses, and lipid metabolism. Studies suggest SIDT1 may influence cancer progression, neurodegeneration, and metabolic disorders by modulating RNA-based signaling. Its expression varies across tissues, with elevated levels observed in certain cancers, linking it to tumor microenvironment interactions.
The antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to map SIDT1 expression, localization, and interactions. Recent work also explores its potential in therapeutic RNA delivery systems. Despite progress, SIDT1's exact molecular mechanisms remain under investigation, emphasizing the antibody's critical role in elucidating its biological and pathological significance.
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