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Rabbit Polyclonal BAIAP2L2(N-term) Antibody

  • 中文名： BAIAP2L2 (N-term)抗体
  • 别    名： Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, BAI1-associated protein 2-like protein 2, Planar intestinal- and kidney-specific BAR domain protein, Pinkbar, BAIAP2L2
货号: IPDX31300
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, BAI1-associated protein 2-like protein 2, Planar intestinal- and kidney-specific BAR domain protein, Pinkbar, BAIAP2L2
Entrez GeneID80115
WB Predicted band size59.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis BAIAP2L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-127 amino acids from the N-terminal region of human BAIAP2L2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于BAIAP2L2 (N-term)抗体的示例参考文献(内容为虚构示例，实际文献请通过学术数据库检索)：

1. **《BAIAP2L2 regulates synaptic plasticity through actin remodeling in hippocampal neurons》**

- 作者：Chen L, et al.

- 摘要：本研究利用BAIAP2L2 (N-term)抗体进行免疫沉淀和免疫荧光实验，发现BAIAP2L2通过调控F-actin动态影响海马神经元树突棘的形成，揭示了其在突触可塑性中的关键作用。

2. **《BAIAP2L2 overexpression promotes tumor metastasis via EGFR signaling》**

- 作者：Wang X, et al.

- 摘要：通过Western blot和免疫组化(使用N-term特异性抗体)，作者发现BAIAP2L2在乳腺癌中高表达，并通过增强EGFR信号通路促进肿瘤细胞的侵袭和转移。

3. **《Structural insights into the BAR domain protein BAIAP2L2》**

- 作者：Saito K, et al.

- 摘要：该研究通过结合N端抗体标记和冷冻电镜技术，解析了BAIAP2L2的BAR结构域如何介导细胞膜曲率感知，为理解其膜重塑功能提供结构基础。

4. **《BAIAP2L2 interacts with dynamin-2 during endocytosis》**

- 作者：Gomez-Castro R, et al.

- 摘要：利用BAIAP2L2 (N-term)抗体进行共免疫沉淀实验，证实其与动力蛋白-2(dynamin-2)的相互作用，揭示了该蛋白在网格蛋白介导的内吞途径中的新机制。

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**提示**：以上为示例性内容，真实文献需通过PubMed、Google Scholar等平台以关键词"BAIAP2L2 antibody"或"BAIAP2L2 N-terminal"检索，并关注抗体应用相关的功能研究或技术验证类文章。

背景信息

BAIAP2L2 (N-term) antibody targets the N-terminal region of the Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2 (BAIAP2L2), a protein encoded by the BAIAP2L2 gene. This antibody is commonly used in research to detect and study BAIAP2L2 expression, localization, and function in various biological contexts. BAIAP2L2 belongs to the BAIAP2 protein family, characterized by their BAR (Bin/Amphiphysin/Rvs) domains, which are involved in membrane curvature sensing and cytoskeletal organization. The protein plays roles in cell migration, neurite outgrowth, and synaptic plasticity, particularly in neuronal tissues. Its N-terminal region is critical for interactions with other signaling molecules and membrane dynamics. Dysregulation of BAIAP2L2 has been implicated in neurodevelopmental disorders and cancer progression. Researchers utilize the BAIAP2L2 (N-term) antibody in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore its expression patterns in brain tissues, cancer cells, or model organisms. The antibody’s specificity for the N-terminal epitope ensures minimal cross-reactivity with homologous proteins like BAIAP2L1. Validation typically includes knockout controls or peptide blocking assays to confirm target recognition. Commercial sources often provide species reactivity (e.g., human, mouse, rat) and application-specific optimization data to support experimental reproducibility.

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