| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ligand of Numb protein X 2, Numb-binding protein 2, PDZ domain-containing RING finger protein 1, LNX2, PDZRN1 |
| Entrez GeneID | 222484 |
| WB Predicted band size | 76.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human LNX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LNX2抗体的3篇参考文献示例，涵盖不同研究方向和抗体应用场景：
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1. **文献名称**：*LNX2 Antibody Validation for Neural Stem Cell Differentiation Studies*
**作者**：Kim et al.
**摘要**：本研究开发并验证了一种兔源多克隆LNX2抗体，通过免疫印迹和免疫荧光技术证实其在啮齿类神经干细胞中的特异性。抗体成功用于揭示LNX2在Notch信号通路调控中的关键作用，为神经发育机制提供了新见解。
2. **文献名称**：*Overexpression of LNX2 in Colorectal Cancer: A Novel Biomarker Identified by Monoclonal Antibody Staining*
**作者**：Zhang et al.
**摘要**：团队制备了高特异性小鼠抗人LNX2单克隆抗体，并通过组织微阵列分析发现LNX2在结直肠癌组织中显著高表达，且与患者预后不良相关，提示其作为潜在肿瘤标志物的价值。
3. **文献名称**：*LNX2 Interactome Profiling Using Co-Immunoprecipitation with a Novel Polyclonal Antibody*
**作者**：Müller et al.
**摘要**：利用新开发的羊多克隆LNX2抗体进行免疫共沉淀-质谱分析，鉴定了多个与LNX2互作的泛素化调控蛋白，揭示了其在细胞周期进程中的未知功能网络。
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**注**：以上文献为示例性内容，实际研究中建议通过PubMed或Web of Science等平台以“LNX2 antibody”及“LNX2 function”等关键词检索最新文献。
The LNX2 antibody is a tool used to detect Ligand of Numb Protein-X 2 (LNX2), an E3 ubiquitin ligase involved in protein ubiquitination and degradation. LNX2. part of the LNX protein family, contains multiple PDZ domains that mediate protein-protein interactions and a RING domain conferring ubiquitin ligase activity. It interacts with NUMB, a regulator of Notch signaling, influencing cell differentiation, polarity, and fate determination. LNX2 ubiquitinates substrates like PTEN or NCAM, modulating signaling pathways linked to neurodevelopment, cancer, and synaptic plasticity.
Research highlights LNX2's dual roles: it may act as a tumor suppressor in glioblastoma by promoting NUMB degradation, yet exhibit oncogenic properties in breast cancer by enhancing cell migration. Dysregulation of LNX2 is implicated in neurological disorders and tumorigenesis, making it a potential biomarker or therapeutic target.
The LNX2 antibody is widely used in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to study LNX2 expression, localization, and interactions. Validated in knockout controls, it helps elucidate LNX2's tissue-specific functions and mechanisms. Commercial antibodies vary in species reactivity (human, mouse, rat) and clonal specificity, requiring careful selection based on experimental needs. Ongoing studies continue to explore LNX2's diverse roles in cellular processes and disease pathogenesis.
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