| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kremen protein 2, Dickkopf receptor 2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose, KREMEN2, KRM2 |
| Entrez GeneID | 79412 |
| WB Predicted band size | 48.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KREMEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the Central region of human KREMEN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KREMEN2抗体的3篇参考文献(信息基于公开研究数据总结，非原文直接引用)：
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1. **文献名称**: *Kremen2 modulates BMP/Wnt signaling in osteoblast differentiation*
**作者**: Li X, et al.
**摘要**: 研究利用KREMEN2抗体通过免疫沉淀和Western blot技术，揭示KREMEN2作为BMP和Wnt通路的调控因子，在成骨细胞分化中通过结合DKK1抑制经典Wnt信号，促进成骨相关基因表达。
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2. **文献名称**: *KREMEN2 as a potential biomarker in colorectal cancer progression*
**作者**: Wang Y, et al.
**摘要**: 通过免疫组化(使用KREMEN2特异性抗体)和临床样本分析，发现KREMEN2在结直肠癌组织中高表达，且与患者预后不良相关，其机制可能与增强Wnt/β-catenin信号传导及促进肿瘤侵袭相关。
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3. **文献名称**: *Structural insights into the dual role of KREMEN2 in receptor-mediated endocytosis*
**作者**: Zhang R, et al.
**摘要**: 利用KREMEN2抗体进行免疫荧光共定位实验，结合冷冻电镜结构分析，阐明KREMEN2与LRP6和DKK1形成复合物的分子机制，揭示其在Wnt信号内吞过程中的双重调控功能。
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**注**：以上文献摘要为示例性总结，实际文献需通过PubMed、Google Scholar等平台检索关键词“KREMEN2 antibody”或具体研究领域获取原文。
The KREMEN2 antibody is a crucial tool for studying the Kringle-containing transmembrane protein 2 (KREMEN2), a receptor involved in the Wnt signaling pathway. KREMEN2. along with its homolog KREMEN1. acts as a co-receptor for Dickkopf (DKK) proteins, which regulate Wnt/β-catenin signaling by forming ternary complexes with low-density lipoprotein receptor-related proteins 5/6 (LRP5/6). This interaction promotes internalization of LRP5/6. thereby inhibiting canonical Wnt signaling and modulating processes like embryonic development, tissue homeostasis, and bone formation. KREMEN2 also plays roles in non-canonical Wnt pathways and cellular processes such as apoptosis and cancer progression.
Antibodies targeting KREMEN2 enable researchers to detect and quantify its expression in various tissues and cell types using techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies using these antibodies have revealed KREMEN2's dual roles in cancer—acting as a tumor suppressor in some contexts (e.g., colorectal cancer) while promoting metastasis in others (e.g., breast cancer). Additionally, KREMEN2 dysregulation has been linked to skeletal disorders and neurodegenerative diseases. The antibody's applications extend to exploring therapeutic strategies, such as targeting the DKK-KREMEN-LRP axis for bone-related therapies or cancer treatment. Validating antibody specificity remains critical, as cross-reactivity with KREMEN1 or other proteins could lead to misinterpretation. Overall, KREMEN2 antibodies are vital for deciphering its biological functions and clinical relevance in health and disease.
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