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Rabbit Polyclonal HIST1H2AB(N-term) Antibody

  • 中文名: HIST1H2AB (N-term)抗体
  • 别    名: Histone H2A type 1-B/E, Histone H2A2, Histone H2A/a, Histone H2A/m, HIST1H2AB, H2AFM
货号: IPDX31212
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是3篇关于HIST1H2AB(N-term)抗体的参考文献(示例为虚构,仅供格式参考):

1. **文献名称**: *Histone H2A variants in chromatin dynamics*

**作者**: Smith J, et al.

**摘要**: 研究分析了HIST1H2AB的N端结构域在染色质重塑中的作用,通过特异性抗体(N-term)进行ChIP-seq,揭示其在基因沉默区域的富集模式。

2. **文献名称**: *Post-translational modifications of HIST1H2AB in cancer*

**作者**: Lee S, et al.

**摘要**: 使用HIST1H2AB(N-term)抗体进行免疫组化,发现该蛋白在乳腺癌中异常乙酰化,与患者预后显著相关。

3. **文献名称**: *Antibody validation for histone H2A isoforms*

**作者**: García-Ruiz C, et al.

**摘要**: 验证了HIST1H2AB(N-term)抗体的特异性,通过Western blot和免疫荧光证明其在区分H2A家族成员中的可靠性。

4. **文献名称**: *Role of HIST1H2AB in embryonic development*

**作者**: Wang X, et al.

**摘要**: 利用N端抗体研究HIST1H2AB在小鼠胚胎干细胞中的表达动态,发现其缺失导致早期发育停滞。

(注:以上文献为示例,实际引用需查询PubMed等数据库获取真实文献。)

背景信息

The HIST1H2AB (N-term) antibody is a tool used to detect the N-terminal region of histone H2A type 1-B, a core component of nucleosomes. Histones, including H2A, play essential roles in DNA packaging and epigenetic regulation by organizing chromatin into structural units. The HIST1H2AB gene, part of the HIST1 cluster on chromosome 6. encodes a replication-dependent histone involved in maintaining chromatin integrity and modulating gene expression. The N-terminal tail of H2A undergoes post-translational modifications (e.g., phosphorylation, ubiquitination) that influence chromatin remodeling, DNA repair, and transcriptional activity. This antibody specifically targets the N-terminal epitope, enabling researchers to study H2A dynamics in processes like cell cycle progression, apoptosis, and epigenetic inheritance. It is widely used in techniques such as chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to investigate histone modification patterns in cancer, developmental biology, and stem cell research. Validation of this antibody often includes knockout controls or peptide blocking to confirm specificity, as cross-reactivity with other H2A variants can occur. Its applications extend to understanding diseases linked to chromatin dysregulation, such as cancers and genetic disorders.

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