| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CXADR-like membrane protein, Adipocyte adhesion molecule, Coxsackie- and adenovirus receptor-like membrane protein, CAR-like membrane protein, CLMP, ACAM, ASAM |
| Entrez GeneID | 79827 |
| WB Predicted band size | 41.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ASAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human ASAM. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于抗平滑肌抗体(ASMA，即Anti-Smooth Muscle Antibody)的3篇代表性文献，简要概括其内容：
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1. **文献名称**：*Autoimmune hepatitis: Diagnostic criteria, subclassifications, and clinical features*
**作者**：Czaja, A.J.
**摘要**：该综述系统分析了ASMA在自身免疫性肝炎(AIH)诊断中的关键作用，指出高滴度ASMA(>1:80)是I型AIH的重要血清学标志物，并与疾病活动度及组织学损伤相关。
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2. **文献名称**：*Autoantibodies in childhood autoimmune liver disease*
**作者**：Gregorio, G.V. et al.
**摘要**：研究比较了儿童AIH患者中ASMA与其他抗体(如ANA)的分布差异，发现ASMA阳性患儿更易出现急性起病，且对免疫抑制治疗反应更敏感。
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3. **文献名称**：*Clinical significance of smooth muscle antibody in autoimmune liver diseases*
**作者**：Verdonk, R.C. et al.
**摘要**：该研究探讨了ASMA在原发性胆汁性肝硬化(PBC)与AIH重叠综合征中的意义，提出ASMA联合线粒体抗体(AMA)检测可提高重叠综合征的早期识别率。
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**注**：ASMA主要用于自身免疫性肝炎(I型)的诊断，若需其他类型ASAM抗体(如神经疾病相关抗体)的研究，建议补充更具体的关键词。
Anti-Synaptic Adhesion Molecule (ASAM) antibodies are autoantibodies targeting synaptic adhesion proteins, which play critical roles in maintaining neural connectivity and synaptic plasticity. These antibodies have gained attention in neuroimmunology due to their potential involvement in autoimmune encephalitis and neuropsychiatric disorders. Synaptic adhesion molecules, such as neurexin, neuroligin, and LRRTMs, facilitate cell-cell interactions, synapse formation, and signal transduction. Dysregulation of these proteins or immune-mediated attacks against them may disrupt synaptic function, contributing to neurological or psychiatric symptoms.
ASAM antibodies are detected via cell-based assays or immunohistochemistry using brain tissue. Their clinical relevance is still under investigation, but associations have been proposed with conditions like autoimmune encephalitis, schizophrenia, and autism spectrum disorders. Notably, they differ from well-characterized neural antibodies (e.g., anti-NMDAR) by targeting adhesion rather than receptor/channel proteins. Research challenges include standardizing detection methods and clarifying pathogenic mechanisms—whether they directly impair synaptic adhesion or serve as disease biomarkers. Current studies focus on linking specific ASAM subtypes to clinical phenotypes and exploring immunotherapies for antibody-associated neurological dysfunction. Understanding ASAM antibodies may advance diagnostics and targeted treatments for synaptic autoimmune disorders.
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