| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Torsin-1B, Torsin ATPase-1B, 364-, Torsin family 1 member B, TOR1B, DQ1 |
| Entrez GeneID | 27348 |
| WB Predicted band size | 38.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TOR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human TOR1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于TOR1B抗体的3篇参考文献，按您的要求整理：
1. **"Characterization of TorsinB, a member of the AAA+ ATPase family localized to the endoplasmic reticulum"**
- 作者：K.L. Kamm et al.
- 摘要：研究通过生成特异性TOR1B抗体，揭示了TOR1B在内质网中的定位，并发现其ATP酶活性对维持内质网结构至关重要，抗体用于免疫印迹和免疫荧光验证蛋白表达。
2. **"Differential expression and function of Torsin family proteins"**
- 作者：M. Jokhi et al.
- 摘要：利用TOR1B抗体比较Torsin家族成员(如TOR1A和TOR1B)的组织分布差异，发现TOR1B在小脑和肝脏中高表达，抗体特异性通过siRNA敲低实验验证。
3. **"TOR1B interacts with nuclear envelope components and regulates neuronal cell viability"**
- 作者：S. Zhao et al.
- 摘要：通过TOR1B抗体进行共免疫沉淀实验，发现其与核膜蛋白LAP1的相互作用，并证明TOR1B缺失导致神经元细胞凋亡增加，抗体用于体外和体内模型的功能研究。
这些文献均涉及TOR1B抗体的开发或应用，聚焦于蛋白定位、功能及相互作用机制。如需具体文章链接或出版信息，可进一步提供。
The TOR1B antibody is a tool used to study Torsin family member 1B (TOR1B), a protein belonging to the AAA+ (ATPases Associated with diverse cellular Activities) superfamily. TOR1B is closely related to TOR1A (TorsinA), with which it shares ~70% amino acid sequence homology. Both are endoplasmic reticulum (ER)-localized ATPases implicated in cellular processes such as protein folding, membrane trafficking, and nuclear envelope dynamics. TOR1B is ubiquitously expressed and interacts with cofactors like LAP1 and LULL1. which regulate its ATPase activity. While TOR1A mutations are linked to early-onset torsion dystonia (DYT1), TOR1B’s precise physiological role remains less defined. Studies suggest functional redundancy or compensation between TOR1A and TOR1B, though TOR1B knockout models display milder phenotypes compared to TOR1A-deficient systems.
TOR1B antibodies are essential for detecting protein expression, localization, and interactions in techniques like Western blotting, immunofluorescence, or immunoprecipitation. They help investigate TOR1B’s involvement in ER stress response, neuronal development, and nuclear membrane integrity. Commercial antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and require validation for specificity due to homology with TOR1A. Recent research explores TOR1B’s potential role in neurodegenerative diseases and its interplay with viral pathogens, highlighting its emerging significance in cellular homeostasis and disease mechanisms.
×
