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Rabbit Polyclonal DNAJB6 Antibody

  • 中文名： DNAJB6抗体
  • 别    名： DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1
货号: IPDX31097
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1
Entrez GeneID10049
WB Predicted band size36.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis DNAJB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the Central region of human DNAJB6.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于DNAJB6抗体的相关文献概述：

1. **"DNAJB6 chaperones Hsp70 to suppress protein aggregation"**

*作者：Hageman J et al.*

摘要：研究揭示了DNAJB6通过招募Hsp70抑制多种致病蛋白(如亨廷顿蛋白和α-突触核蛋白)的异常聚集，其抗体被用于检测DNAJB6在细胞模型中的分子伴侣活性。

2. **"DNAJB6 is a candidate biomarker for hepatocellular carcinoma"**

*作者：Sun Y et al.*

摘要：该文献发现肝癌组织中DNAJB6表达显著上调，利用特异性抗体验证其与患者不良预后的相关性，提示DNAJB6可能作为肝癌诊断标志物。

3. **"DNAJB6 mutations cause dominant limb-girdle muscular dystrophy"**

*作者：Sarparanta J et al.*

摘要：研究通过抗体检测发现DNAJB6突变导致其在肌纤维中错误定位，破坏对肌原纤维蛋白的折叠调控，从而引发肌营养不良症的病理机制。

4. **"Antibody-based profiling of DNAJB6 in amyloidogenic diseases"**

*作者：Kakkar V et al.*

摘要：开发了高特异性DNAJB6抗体，验证其在阿尔茨海默病和帕金森病模型中抑制β-淀粉样蛋白沉积的功能，强调其治疗潜力。

注：以上为虚拟文献示例，实际研究需通过PubMed/Google Scholar检索关键词“DNAJB6 antibody”获取。

背景信息

The DNAJB6 antibody is a research tool targeting the DNAJB6 protein, a member of the HSP40/DNAJ family of molecular chaperones. DNAJB6 functions as a co-chaperone, interacting with HSP70 to regulate protein folding, prevent aggregation, and manage cellular stress responses. It is particularly notable for its role in suppressing the aggregation of amyloidogenic proteins, such as those linked to neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), and in muscular disorders like limb-girdle muscular dystrophy. Structurally, DNAJB6 contains a conserved J-domain critical for HSP70 binding, a glycine/phenylalanine-rich (G/F) region, and a C-terminal substrate-binding domain. Unlike many DNAJ proteins, DNAJB6 lacks a transmembrane domain and exists in two isoforms (α and β) with distinct subcellular localizations—nuclear (α) and cytoplasmic (β). Antibodies against DNAJB6 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interaction partners in disease models. Research highlights its dual roles in cancer (acting as both tumor suppressor and promoter depending on context) and its potential as a biomarker for conditions involving proteotoxic stress. These antibodies are vital for elucidating DNAJB6’s mechanisms in protein quality control and its therapeutic relevance in protein-misfolding disorders.

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