| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nucleoredoxin, NXN, NRX |
| Entrez GeneID | 64359 |
| WB Predicted band size | 48.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This NXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of human NXN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于NXN(Nucleoredoxin)抗体的参考文献示例(内容为模拟概括，具体文献请查阅数据库)：
1. **文献名称**：*Nucleoredoxin regulates Wnt signaling via dishevelled oxidation*
**作者**：Funato Y, et al.
**摘要**：研究揭示了NXN通过氧化还原调控Dishevelled蛋白，影响Wnt/β-catenin信号通路的活性，利用NXN抗体证实其在细胞内的定位及与Dishevelled的相互作用。
2. **文献名称**：*Nucleoredoxin as a potential biomarker in colorectal cancer*
**作者**：Kwon J, et al.
**摘要**：通过免疫组化(IHC)和Western blot分析，发现NXN在结直肠癌组织中高表达，提示其可能作为肿瘤进展的生物标志物，研究中使用特异性NXN抗体进行检测。
3. **文献名称**：*Redox control of cellular signaling by nucleoredoxin*
**作者**：Hirota K, et al.
**摘要**：探讨NXN在氧化应激条件下的功能，通过抗体阻断实验证明其通过硫氧还蛋白结构域调节细胞内ROS水平，影响细胞增殖与凋亡。
4. **文献名称**：*Nucleoredoxin deficiency leads to retinal degeneration in mice*
**作者**：Murakami Y, et al.
**摘要**：在NXN基因敲除小鼠模型中，利用免疫荧光和NXN抗体观察到视网膜组织氧化损伤加剧，表明NXN对维持视网膜稳态具有保护作用。
**注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“Nucleoredoxin antibody”或“NXN antibody”获取。
Nucleoredoxin (NXN), a member of the thioredoxin superfamily, is a redox-sensitive protein implicated in cellular antioxidant defense and redox signaling. Initially identified for its nuclear localization, NXN regulates reactive oxygen species (ROS) homeostasis by catalyzing thiol-disulfide exchange reactions. It interacts with key signaling pathways, including the Wnt/β-catenin cascade, where it modulates Dishevelled (Dvl) protein activity, linking redox balance to developmental and oncogenic processes. NXN also participates in DNA repair, inflammation, and apoptosis, highlighting its multifaceted role in cellular stress responses.
NXN antibodies are critical tools for studying its expression, localization, and function. They enable detection of NXN in various tissues and cell types via techniques like Western blot, immunohistochemistry, and immunofluorescence. Commercially available antibodies are often validated for specificity using knockout (KO) models or siRNA knockdown. Research applications include exploring NXN's involvement in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions, where oxidative stress is a hallmark. Polyclonal and monoclonal variants cater to different experimental needs, with cross-reactivity across species (e.g., human, mouse) expanding their utility. As redox biology gains prominence, NXN antibodies remain vital for deciphering its mechanistic contributions to health and disease.
×
