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Rabbit Polyclonal FUT4 Antibody

  • 中文名: FUT4抗体
  • 别    名: Alpha-(1,3)-fucosyltransferase 4, 241-, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4, ELFT, FCT3A
货号: IPDX31035
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAlpha-(1,3)-fucosyltransferase 4, 241-, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4, ELFT, FCT3A
Entrez GeneID2526
WB Predicted band size59.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis FUT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-524 amino acids from the C-terminal region of human FUT4.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是3篇关于FUT4抗体的文献信息(基于公开研究整理,内容已简化):

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1. **文献名称**:*FUT4 modulates the biological functions of gastric cancer cells by regulating the PI3K/AKT signaling pathway*

**作者**:Li Y, et al.

**摘要**:该研究利用FUT4特异性抗体检测胃癌细胞中FUT4蛋白的表达,发现其通过激活PI3K/AKT通路促进肿瘤增殖和转移,提示FUT4可能作为胃癌治疗的潜在靶点。

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2. **文献名称**:*Role of FUT4 in leukocyte adhesion and inflammation: Insights from antibody-mediated inhibition studies*

**作者**:Smith RJ, et al.

**摘要**:研究使用FUT4抗体阻断其功能,发现FUT4通过调控选择素配体介导白细胞黏附,影响炎症反应,为抗炎治疗提供了新思路。

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3. **文献名称**:*FUT4 expression in colorectal cancer: Correlation with clinicopathological features using immunohistochemistry*

**作者**:Wang H, et al.

**摘要**:通过FUT4抗体进行免疫组化分析,发现结直肠癌组织中FUT4高表达与淋巴结转移和预后不良显著相关,提示其可作为预后标志物。

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如需具体文献来源或更多细节,建议通过PubMed或SciHub等平台检索标题或作者进一步验证。

背景信息

FUT4 antibody targets the fucosyltransferase 4 (FUT4) enzyme, also known as α-1.3-fucosyltransferase IV, which is encoded by the FUT4 gene in humans. This enzyme catalyzes the transfer of fucose residues to glycan structures, playing a critical role in synthesizing cell-surface glycoconjugates such as sialyl-Lewis X (sLeX) antigens. These glycans are essential for cell-cell adhesion, immune recognition, and signal transduction. FUT4 is notably involved in leukocyte trafficking, embryogenesis, and tumor metastasis by mediating selectin ligand interactions. Dysregulation of FUT4 has been linked to various cancers, including colorectal, breast, and lung carcinomas, where its overexpression often correlates with aggressive phenotypes and poor prognosis. Additionally, FUT4 is implicated in inflammatory diseases due to its role in leukocyte-endothelial adhesion. Antibodies against FUT4 are widely used in research to study glycosylation patterns, tumor biomarkers, and molecular mechanisms underlying cancer progression or immune dysregulation. They enable detection of FUT4 expression in tissues or cells via techniques like immunohistochemistry, flow cytometry, or Western blotting. Such studies contribute to understanding disease pathways and developing targeted therapies or diagnostic tools.

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