| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protocadherin gamma-A8, PCDH-gamma-A8, PCDHGA8, KIAA0327 |
| Entrez GeneID | 9708 |
| WB Predicted band size | 101.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PCDHGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-808 amino acids from the C-terminal region of human PCDHGA8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PCDHGA8抗体的虚构参考文献示例(仅供学术示例参考，非真实文献)：
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1. **文献名称**: *Characterization of a Novel Monoclonal Antibody Against PCDHGA8 for Neuronal Development Studies*
**作者**: Li, X. et al.
**摘要**: 本研究开发了一种针对PCDHGA8蛋白的高特异性单克隆抗体，验证了其在免疫组化和Western blot中的应用。结果显示，PCDHGA8在小鼠大脑皮层神经元中高表达，可能参与突触形成的调控。
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2. **文献名称**: *PCDHGA8 Expression in Glioblastoma: Insights from Immunohistochemical Analysis*
**作者**: Rodriguez, S. & Kumar, P.
**摘要**: 通过使用商业化PCDHGA8抗体，作者发现该蛋白在胶质母细胞瘤组织中异常高表达，并与肿瘤侵袭性相关，提示其可能作为潜在治疗靶点。
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3. **文献名称**: *Functional Role of PCDHGA8 in Cell-Cell Adhesion Revealed by Antibody Blockade Experiments*
**作者**: Chen, H. et al.
**摘要**: 利用特异性抗体阻断PCDHGA8功能后，研究者观察到上皮细胞间粘附能力显著下降，表明PCDHGA8在维持组织屏障完整性中起关键作用。
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4. **文献名称**: *Development of a Rabbit Polyclonal Antibody for PCDHGA8 and Its Application in Autism Spectrum Disorder Models*
**作者**: Park, J. & Kim, T.
**摘要**: 该文献报道了一种兔源多克隆抗体的制备，并应用于自闭症模型小鼠脑组织分析，发现PCDHGA8表达异常可能与神经发育障碍相关。
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注：以上文献为模拟示例，实际研究中请通过权威数据库(如PubMed、Web of Science)查询真实发表的文章。
The protocadherin gamma subfamily A8 (PCDHGA8) antibody is a research tool designed to detect and study the PCDHGA8 protein, a member of the protocadherin gamma gene cluster. Protocadherins are transmembrane proteins involved in cell-cell adhesion, neural circuit formation, and synaptic specificity in the central nervous system. The PCDHGA8 gene, located on human chromosome 5q31. encodes a calcium-dependent cell adhesion molecule with six extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic tail. It plays a role in neuronal development, including axon guidance, dendrite arborization, and synapse establishment.
PCDHGA8 antibodies are commonly used in techniques like immunohistochemistry (IHC), western blotting (WB), and immunofluorescence (IF) to investigate its expression patterns, localization, and function in biological samples. Studies have explored its potential involvement in neurological disorders, cancer progression, and neurodevelopmental conditions. For instance, aberrant PCDHGA8 expression has been linked to synaptic dysfunction and certain malignancies. These antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human PCDHGA8 protein, though cross-reactivity with homologous proteins in model organisms (e.g., mice) may require validation. Researchers rely on these antibodies to unravel PCDHGA8's role in cellular signaling pathways and tissue-specific interactions.
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