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Rabbit Polyclonal RPS19 Antibody

  • 中文名: RPS19抗体
  • 别    名: 40S ribosomal protein S19, RPS19
货号: IPDX31032
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases40S ribosomal protein S19, RPS19
Entrez GeneID6223
WB Predicted band size16.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the Central region of human RPS19.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于RPS19抗体的参考文献(信息基于公开文献总结,部分为模拟示例):

1. **标题**:*Ribosomal protein S19 deficiency in Diamond-Blackfan anemia: functional insights from pathogenic mutations*

**作者**:Gazda HT et al.

**摘要**:研究通过Western blot和免疫荧光技术使用RPS19抗体,揭示了RPS19基因突变导致核糖体合成异常,进而引发Diamond-Blackfan贫血的分子机制。

2. **标题**:*RPS19 interacts with MYC and regulates oncogenic activity in colorectal cancer*

**作者**:Wang Y et al.

**摘要**:通过免疫共沉淀(Co-IP)和ChIP实验结合RPS19抗体,证明RPS19与MYC蛋白相互作用,促进结直肠癌细胞增殖,提示其作为潜在治疗靶点。

3. **标题**:*Development of a high-specificity monoclonal antibody for RPS19 and its diagnostic application*

**作者**:Li X et al.

**摘要**:报道了一种新型RPS19单克隆抗体的制备与验证,该抗体在ELISA和免疫组化中表现出高灵敏度和特异性,可用于临床样本检测。

4. **标题**:*RPS19 regulates p53 pathway via MDM2 in hepatocellular carcinoma*

**作者**:Chen L et al.

**摘要**:利用RPS19抗体进行组织芯片分析,发现RPS19通过调控MDM2-p53信号通路影响肝癌进展,为靶向治疗提供依据。

(注:以上文献标题及作者为示例性质,具体内容需根据真实文献调整。建议通过PubMed或Google Scholar以“RPS19 antibody”为关键词检索最新研究。)

背景信息

The Ribosomal Protein S19 (RPS19) is a component of the 40S ribosomal subunit, playing a critical role in ribosome biogenesis and protein synthesis. Dysregulation or mutations in the RPS19 gene are associated with Diamond-Blackfan anemia (DBA), a rare inherited bone marrow failure disorder characterized by defective erythroid progenitor maturation. RPS19 antibodies are essential tools for studying its expression, localization, and functional interactions in both normal and disease contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RPS19 levels in cellular or tissue samples, aiding research on ribosomopathies, cancer, and other conditions linked to ribosomal dysfunction. Studies also utilize RPS19 antibodies to explore its extraribosomal roles, such as modulating cell proliferation, apoptosis, and angiogenesis. Validation of antibody specificity—through knockout controls or siRNA knockdown—is crucial due to potential cross-reactivity with other ribosomal proteins. Monoclonal and polyclonal RPS19 antibodies offer varying sensitivity and application flexibility, supporting both basic research and clinical diagnostics. Understanding RPS19's molecular mechanisms through antibody-based assays contributes to therapeutic development for DBA and cancers where RPS19 overexpression or mutation is implicated.

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