| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-A6, Homeobox protein Hox-1B, HOXA6, HOX1B |
| Entrez GeneID | 3203 |
| WB Predicted band size | 26.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This HOXA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the Central region of human HOXA6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于学术文献特征的模拟示例(实际文献需通过数据库验证)：
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1. **文献名称**: *HOXA6 expression in colorectal cancer: association with clinicopathological characteristics*
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化(使用HOXA6抗体)检测结直肠癌组织中HOXA6蛋白表达，发现其高表达与肿瘤分期和转移显著相关，提示HOXA6可能作为预后标志物。
2. **文献名称**: *Developmental regulation of HOXA6 in murine embryogenesis*
**作者**: Smith JL, et al.
**摘要**: 利用HOXA6特异性抗体进行小鼠胚胎组织染色，揭示该基因在肢体发育和神经管形成中的时空表达模式，支持其在胚胎形态发生中的作用。
3. **文献名称**: *HOXA6 modulates TGF-β signaling in lung adenocarcinoma*
**作者**: Chen R, et al.
**摘要**: 通过Western blot和免疫荧光(使用HOXA6抗体)证明HOXA6通过调控TGF-β通路影响肺癌细胞侵袭，为靶向治疗提供潜在靶点。
4. **文献名称**: *Antibody validation for HOXA6 in human pancreatic tissues*
**作者**: Gupta S, et al.
**摘要**: 系统验证多种HOXA6抗体的特异性，比较其在人胰腺组织中的染色效果，为后续研究提供可靠的实验工具选择依据。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Web of Science等平台检索确认。建议使用关键词“HOXA6 antibody”、“HOXA6 immunohistochemistry”或结合具体研究领域(如“HOXA6 cancer”)进行精准查询。
The HOXA6 antibody is a crucial tool for studying the HOXA6 protein, a member of the Homeobox (HOX) gene family. HOX genes encode transcription factors that regulate embryonic development, particularly body patterning and organogenesis along the anterior-posterior axis. HOXA6. located on chromosome 7p15.2. plays roles in segmental identity during embryogenesis, with emerging implications in hematopoiesis, skeletal development, and neural differentiation. Dysregulation of HOXA6 has been linked to developmental disorders and cancers, such as leukemia and colorectal tumors, where its aberrant expression may drive oncogenesis or metastasis.
HOXA6 antibodies are typically monoclonal or polyclonal reagents designed to detect and quantify HOXA6 protein levels in various experimental settings, including Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies enable researchers to investigate HOXA6's spatial-temporal expression, post-translational modifications, and interactions with regulatory pathways. Validation often involves knockout cell lines or tissue-specific expression patterns to confirm specificity. Recent studies also utilize HOXA6 antibodies to explore its role in cancer stem cell maintenance and therapeutic resistance, highlighting its potential as a biomarker or drug target. Proper antibody selection and optimization are critical due to homology among HOX family proteins.
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