| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Polypeptide N-acetylgalactosaminyltransferase 4, Polypeptide GalNAc transferase 4, GalNAc-T4, pp-GaNTase 4, Protein-UDP acetylgalactosaminyltransferase 4, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4, GALNT4 |
| Entrez GeneID | 100528030;8693 |
| WB Predicted band size | 66.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GALNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of human GALNT4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GALNT4(N-term)抗体的参考文献示例(部分信息为虚构示例，仅供参考)：
1. **文献名称**: *GALNT4-mediated O-glycosylation regulates EGFR signaling in colorectal cancer*
**作者**: Smith A, et al.
**摘要**: 研究通过GALNT4(N-term)抗体检测结直肠癌组织中GALNT4的N端表达，发现其通过O-糖基化修饰EGFR，促进肿瘤侵袭和转移。
2. **文献名称**: *Development and validation of a specific GALNT4 N-terminal antibody for functional studies*
**作者**: Lee H, et al.
**摘要**: 描述了针对GALNT4 N端表位的多克隆抗体的开发与验证，证实其在Western blot和免疫荧光中的特异性，用于研究GALNT4亚细胞定位。
3. **文献名称**: *GALNT4 expression correlates with poor prognosis in hepatocellular carcinoma*
**作者**: Zhang Y, et al.
**摘要**: 使用GALNT4(N-term)抗体分析肝癌患者样本，发现GALNT4高表达与生存率降低相关，提示其作为预后生物标志物的潜力。
4. **文献名称**: *Role of GALNT4 in modulating TGF-β pathway via glycosylation of TβRII*
**作者**: Wang X, et al.
**摘要**: 通过抗体特异性识别GALNT4的N端区域，揭示了GALNT4对TGF-β受体II的糖基化修饰，进而影响TGF-β信号通路活性。
**注意**：以上文献为示例，实际引用需通过PubMed、Google Scholar等平台搜索真实文献(关键词如“GALNT4 antibody”或“GALNT4 N-terminal”)。
The GALNT4 (N-term) antibody is a targeted reagent used to detect the N-terminal region of the polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4), an enzyme in the GALNT family. GALNTs initiate O-linked glycosylation by transferring N-acetylgalactosamine (GalNAc) to serine or threonine residues on proteins, a post-translational modification critical for protein stability, trafficking, and cell-cell interactions. GALNT4 is implicated in diverse biological processes, including lipid metabolism, cardiovascular function, and cancer progression, where aberrant glycosylation is often linked to disease states.
This antibody specifically recognizes epitopes near the N-terminus of GALNT4. a region that may exhibit higher sequence conservation across species, making it useful for cross-species studies. It is commonly employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess GALNT4 expression, localization, and regulation in tissues or cultured cells. Researchers use it to explore GALNT4's role in cellular pathways, its tissue-specific activity, and its association with diseases such as colorectal or prostate cancers, where GALNT4 overexpression has been observed. Validated for specificity in relevant models, the antibody aids in elucidating the functional consequences of GALNT4-mediated glycosylation in health and disease.
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