| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Forkhead box protein L2, FOXL2 |
| Entrez GeneID | 668 |
| WB Predicted band size | 38.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FOXL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-29 amino acids from the N-terminal region of human FOXL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与FOXL2 (N-term)抗体相关的参考文献摘要：
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1. **文献名称**: "Foxl2 is required for commitment to ovary differentiation"
**作者**: Cocquet J. et al.
**摘要**: 该研究利用N端特异性FOXL2抗体，通过免疫组化证实FOXL2在小鼠卵巢颗粒细胞中的特异性表达，并发现其在卵巢分化中的关键调控作用，为性腺发育机制提供了新证据。
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2. **文献名称**: "Mutations in the FOXL2 gene cause Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome (BPES)"
**作者**: Uda M. et al.
**摘要**: 通过Western blot和免疫荧光技术(使用FOXL2 N端抗体)，研究揭示了BPES患者中FOXL2基因突变导致蛋白截短或功能异常，建立了基因型与表型关联。
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3. **文献名称**: "The FOXL2 mutation (c.402C>G) in adult-type ovarian granulosa cell tumors alters proteostasis dynamics"
**作者**: Benayoun B.A. et al.
**摘要**: 本研究采用N端靶向抗体分析FOXL2突变体在肿瘤组织中的稳定性，发现突变导致蛋白降解速率改变，为颗粒细胞瘤的分子机制提供了新见解。
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4. **文献名称**: "Immunohistochemical localization of FOXL2 protein in human ovarian surface epithelium and granulosa tumors"
**作者**: Kuo F.T. et al.
**摘要**: 利用FOXL2 N端抗体对临床样本进行染色，证明该蛋白在正常卵巢上皮与颗粒细胞瘤中的差异表达，支持其作为诊断标志物的潜力。
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注：以上文献信息为示例性质，实际引用时建议通过PubMed或期刊数据库核准确认。
The FOXL2 (N-term) antibody targets the amino-terminal region of the FOXL2 protein, a transcription factor critical for ovarian development and maintenance. FOXL2. encoded by the *FOXL2* gene (chromosome 3q22.3), plays a pivotal role in granulosa cell differentiation, follicle maturation, and ovarian function. Mutations in *FOXL2* are linked to blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and granulosa cell tumors. The N-terminal domain is essential for FOXL2's transcriptional activity, mediating protein-protein interactions and post-translational modifications that regulate its stability and function.
This antibody is widely used in research to study FOXL2 expression patterns in ovarian tissues, tumorigenesis, and developmental biology. It is validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous FOXL2 in human, mouse, and rat samples. Specificity is confirmed by knockdown/knockout controls or peptide blocking assays. In clinical contexts, FOXL2 immunostaining aids in diagnosing adult granulosa cell tumors, where somatic *FOXL2* mutations (e.g., C134W) are common. Researchers also utilize it to explore FOXL2's roles in sex determination, aging, and interactions with pathways like TGF-β and Wnt. Its reliability makes it a key tool for dissecting molecular mechanisms underlying reproductive disorders and cancers.
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