| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARL14 effector protein, ARF7 effector protein, ARL14EP, ARF7EP, C11orf46 |
| Entrez GeneID | 120534 |
| WB Predicted band size | 29.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C11orf46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the C-terminal region of human C11orf46. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是几篇关于C11orf46抗体的假设性参考文献(注：部分文献为示例性描述，实际需根据具体研究验证)：
1. **文献名称**：*C11orf46 overexpression correlates with poor prognosis in glioma and promotes tumor progression*
**作者**：Zhang L, et al.
**摘要**：本研究利用C11orf46特异性抗体通过免疫组化分析发现，C11orf46在胶质瘤组织中显著高表达，且与患者生存率降低相关。功能实验表明其通过调控Wnt/β-catenin通路促进肿瘤侵袭。
2. **文献名称**：*Development of a monoclonal antibody against human C11orf46 for functional characterization*
**作者**：Smith J, et al.
**摘要**：文章报道了一种针对C11orf46蛋白的高亲和力单克隆抗体的开发，验证了其在Western blot和免疫荧光中的特异性，并用于检测C11orf46在多种癌细胞系中的亚细胞定位。
3. **文献名称**：*C11orf46 as a potential biomarker in colorectal cancer: Insights from antibody-based assays*
**作者**：Wang Y, et al.
**摘要**：通过ELISA和免疫组织化学(使用C11orf46抗体)，研究发现结直肠癌患者血清和组织中C11orf46水平升高，提示其可能作为诊断标志物或治疗靶点。
4. **文献名称**：*Functional interaction of C11orf46 with DNA repair pathways revealed by knockdown and antibody-mediated inhibition*
**作者**：Brown K, et al.
**摘要**：利用C11orf46抗体进行蛋白质互作分析，发现其与BRCA1复合物存在相互作用，提示C11orf46可能在DNA损伤修复中发挥调控作用，敲低后导致基因组不稳定性增加。
**注意**：以上文献为示例，实际研究中请通过PubMed或Google Scholar以“C11orf46 antibody”或“C11orf46 function”等关键词检索最新论文。
The C11orf46 antibody targets the protein encoded by the *C11orf46* gene (Chromosome 11 Open Reading Frame 46), a poorly characterized gene located on human chromosome 11. Although its exact biological function remains unclear, *C11orf46* is hypothesized to play roles in cellular processes such as transcriptional regulation or protein interaction, based on conserved structural domains and limited expression data. The gene has drawn attention due to its potential involvement in diseases, including certain cancers and neurological disorders, though mechanistic insights are sparse.
C11orf46 antibodies are primarily used in research to detect and study the expression, localization, and interactions of the C11orf46 protein. These antibodies are typically developed using recombinant protein fragments or synthetic peptides as immunogens. Validation often includes Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) in cell lines or tissue samples, with knockdown models sometimes employed to confirm specificity.
Current literature highlights sporadic associations between C11orf46 dysregulation and tumor progression or neurodevelopmental anomalies, but conclusive evidence is lacking. Challenges in studying this target include low protein abundance, ambiguous subcellular localization, and a lack of well-established functional assays. Despite these limitations, C11orf46 antibodies remain valuable tools for exploratory studies aiming to unravel the gene’s role in health and disease.
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