| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, p70-S6K 2, S6 kinase-related kinase, SRK, Serine/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, S6K-beta, p70 S6 kinase beta, p70 S6K-beta, p70 S6KB, p70-beta, RPS6KB2, STK14B |
| Entrez GeneID | 6199 |
| WB Predicted band size | 53.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RPS6KB2 Monoclonal antibody was raised using purified His-tagged recombinant human RPS6KB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于RPS6KB2抗体的参考文献及摘要概括：
1. **《RPS6KB2 promotes tumor progression through mTOR signaling in hepatocellular carcinoma》**
- 作者：Li X, et al.
- 摘要：研究利用RPS6KB2抗体进行免疫组化，发现该蛋白在肝癌组织中高表达，并通过mTOR通路促进肿瘤侵袭和转移。
2. **《Characterization of RPS6KB2 isoform-specific functions in breast cancer》**
- 作者：Wang Y, Zhang H.
- 摘要：通过Western blot和免疫荧光(使用RPS6KB2抗体)，揭示不同剪接异构体在乳腺癌细胞增殖和化疗耐药中的差异性作用。
3. **《RPS6KB2 as a potential biomarker for ovarian cancer prognosis》**
- 作者：Chen L, et al.
- 摘要：采用RPS6KB2抗体检测卵巢癌患者组织样本，发现其表达水平与患者生存率显著相关，提示其作为预后标志物的潜力。
注：以上文献名为示例性虚构，实际研究需通过PubMed或Google Scholar以关键词“RPS6KB2 antibody”或“RPS6KB2 function”检索真实发表论文。
**Background of RPS6KB2 Antibody**
The ribosomal protein S6 kinase beta-2 (RPS6KB2), also known as S6K2. is a serine/threonine kinase belonging to the AGC kinase family. It plays a critical role in the mTOR (mechanistic target of rapamycin) signaling pathway, which regulates cell growth, proliferation, and survival by integrating nutrient and energy signals. RPS6KB2 shares structural and functional homology with RPS6KB1 (S6K1) but exhibits distinct tissue expression patterns and regulatory mechanisms. While S6K1 is broadly expressed, S6K2 shows higher abundance in specific tissues, including the liver, kidney, and immune cells.
RPS6KB2 antibodies are essential tools for studying the activation, localization, and interaction partners of S6K2 in cellular signaling. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect S6K2 expression, phosphorylation status (e.g., at Thr388/389), and its involvement in diseases like cancer, where mTOR signaling is often dysregulated. Research using RPS6KB2 antibodies has highlighted its role in modulating protein synthesis, ribosome biogenesis, and stress responses, with emerging links to metabolic disorders and tumor progression.
The development of specific RPS6KB2 antibodies has advanced mechanistic insights into mTORC1-dependent and -independent pathways, aiding the exploration of targeted therapies for cancers and other hyperproliferative conditions.
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