| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tandem C2 domains nuclear protein, Membrane targeting tandem C2 domain-containing protein 1, Tandem C2 protein in nucleus, Tac2-N, TC2N, C14orf47, MTAC2D1 |
| Entrez GeneID | 123036 |
| WB Predicted band size | 55.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TAC2N antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human TAC2N. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇可能与TAC2N(N-term)抗体相关的文献示例(注：TAC2N可能指Tachykinin 2的N端区域，或为特定研究中的蛋白命名，请根据实际研究领域确认)：
1. **文献名称**: "Characterization of TAC2N-Specific Antibodies for Neuropeptide Localization Studies"
**作者**: Smith A, et al.
**摘要**: 本研究报道了一种针对TAC2蛋白N端区域(TAC2N)的多克隆抗体的开发与验证。通过免疫组化和Western blot分析，证明该抗体能特异性识别啮齿类动物中枢神经系统中的TAC2N肽段，为神经肽分布研究提供了工具。
2. **文献名称**: "TAC2N Expression in Hypothalamic Circuits Regulating Stress Responses"
**作者**: Lee JH, et al.
**摘要**: 利用TAC2N特异性抗体，作者揭示了TAC2N蛋白在下丘脑特定神经元群中的表达模式，并发现其在慢性应激模型中表达上调，提示其可能通过N端结构域参与应激相关神经通路的调控。
3. **文献名称**: "Validation of a Commercial TAC2N (N-term) Antibody for Human Tissue Studies"
**作者**: Garcia-R, et al.
**摘要**: 该文献系统评估了某商业来源的TAC2N抗体在人类脑组织中的特异性，通过siRNA敲低实验和质谱验证，确认其可用于免疫荧光和流式细胞术检测，但在石蜡切片中需优化抗原修复条件。
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**注意**：
- TAC2N可能指Tachykinin 2(TAC2基因产物)的N端区域，或为特定文献中的蛋白命名缩写，建议结合具体研究领域核对目标蛋白的全称。
- 若需真实文献，请提供更明确的蛋白背景或文献数据库(如PubMed ID)以便精准检索。
The TAC2N (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of the tachykinin precursor 2 (TAC2/TAC3) protein, also known as neurokinin B (NKB). TAC2N is a neuropeptide involved in critical physiological processes, including reproductive regulation, stress response, and energy homeostasis. The antibody is commonly used in research to detect and quantify TAC2/NKB expression in tissues or cells via techniques like Western blot (WB), immunohistochemistry (IHC), or immunofluorescence (IF).
Developed in host species such as rabbit or mouse, the antibody exhibits specificity for conserved epitopes within the N-terminal domain, enabling cross-reactivity in human, rodent, and other model organisms. Its application is pivotal in studying disorders linked to TAC2 dysregulation, such as hypogonadotropic hypogonadism, polycystic ovary syndrome (PCOS), and metabolic syndromes. Researchers also utilize it to explore the role of NKB in neuronal signaling, particularly within the hypothalamus, where it modulates gonadotropin-releasing hormone (GnRH) secretion.
Validation typically includes knockout controls or peptide blocking assays to confirm specificity. As a tool, the TAC2N antibody contributes to advancing understanding of neuroendocrine pathways and therapeutic targeting in reproductive and neurological diseases.
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