| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein diaphanous homolog 2, Diaphanous-related formin-2, DRF2, DIAPH2, DIA |
| Entrez GeneID | 1730 |
| WB Predicted band size | 125.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DIAPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 870-899 amino acids from the Central region of human DIAPH2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DIAPH2抗体的3篇虚构参考文献示例(仅供参考格式)：
1. **文献名称**：DIAPH2抗体在卵巢癌细胞迁移中的功能研究
**作者**：Smith A, et al.
**摘要**：本研究开发了一种高特异性DIAPH2抗体，验证了其在卵巢癌细胞中的表达定位，发现DIAPH2过表达与化疗耐药性增强相关，抑制其活性可降低细胞迁移能力。
2. **文献名称**：DIAPH2作为乳腺癌预后标志物的抗体验证
**作者**：Zhang L, et al.
**摘要**：通过新制备的DIAPH2单克隆抗体，分析乳腺癌组织样本，发现DIAPH2低表达与患者生存率下降显著相关，提示其可能作为潜在预后标志物。
3. **文献名称**：DIAPH2抗体揭示其在细胞有丝分裂中的作用
**作者**：Johnson R, et al.
**摘要**：利用CRISPR敲除结合DIAPH2特异性抗体，证实DIAPH2通过调控微管动力学参与细胞分裂，抗体染色显示其定位在纺锤体区域。
注：以上文献为示例，实际引用需以真实发表的论文为准。
DIAPH2 (Diaphanous-related formin 2) is a member of the formin family of proteins, which regulate actin cytoskeleton dynamics, a critical process for cell motility, division, and morphology. Encoded by the DIAPH2 gene located on the X chromosome, this protein contains formin homology domains (FH1 and FH2) that facilitate actin polymerization and microtubule stabilization. DIAPH2 is implicated in diverse cellular functions, including cytokinesis, cell migration, and maintenance of cell polarity. Its dysregulation has been linked to pathological conditions, particularly cancers such as breast and ovarian cancer, where altered expression may influence tumor invasiveness and metastasis. Additionally, DIAPH2 mutations or deletions are associated with premature ovarian insufficiency (POI), highlighting its role in reproductive health.
DIAPH2 antibodies are essential tools for investigating its expression patterns, subcellular localization, and interactions in both physiological and disease contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein levels in tissue samples or cell lines. Research utilizing DIAPH2 antibodies has contributed to understanding its involvement in signaling pathways, such as the Rho GTPase-mediated regulation of cytoskeletal remodeling. Furthermore, studies explore its potential as a biomarker or therapeutic target, particularly in cancers with cytoskeletal dysregulation. Commercial DIAPH2 antibodies are typically validated for specificity across human, mouse, and rat models, enabling cross-species comparative studies. Ongoing research continues to unravel its multifaceted roles in development and disease.
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