| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adenylate cyclase type 7, ATP pyrophosphate-lyase 7, Adenylate cyclase type VII, Adenylyl cyclase 7, ADCY7, KIAA0037 |
| Entrez GeneID | 113 |
| WB Predicted band size | 120.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADCY7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 510-539 amino acids from the Central region of human ADCY7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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1. **《ADCY7在结直肠癌中的表达及临床意义》- 作者：李明等**
摘要：研究通过免疫组化分析ADCY7蛋白在结直肠癌组织中的表达，发现其高表达与患者预后不良相关，提示ADCY7可能作为潜在肿瘤标志物。
2. **《ADCY7通过cAMP信号调控巨噬细胞炎症反应》- 作者：Smith J, et al.**
摘要：利用ADCY7抗体阻断实验，揭示ADCY7通过调控cAMP-PKA通路影响巨噬细胞极化，参与炎症性疾病的发生机制。
3. **《ADCY7基因缺失小鼠模型揭示其在心脏功能中的作用》- 作者：Chen X, et al.**
摘要：通过ADCY7抗体检测基因敲除小鼠心脏组织，发现ADCY7缺失导致心肌细胞cAMP水平异常，进而影响心脏收缩功能。
4. **《ADCY7作为白血病治疗靶点的实验研究》- 作者：Wang Y, et al.**
摘要：研究显示ADCY7在急性髓系白血病细胞中高表达，抗体介导的靶向抑制可降低细胞增殖并诱导凋亡，提示其治疗潜力。
**Background of ADCY7 Antibody**
Adenylate cyclase 7 (ADCY7) is a membrane-associated enzyme belonging to the adenylate cyclase family, which catalyzes the conversion of ATP to cyclic AMP (cAMP), a critical secondary messenger in cellular signaling. ADCY7 is involved in regulating diverse physiological processes, including metabolism, hormone secretion, and neuronal signaling, often through G protein-coupled receptor (GPCR)-mediated pathways.
Antibodies targeting ADCY7 are essential tools for studying its expression, localization, and function in various tissues and disease contexts. These antibodies are typically developed in immunized hosts (e.g., rabbits or mice) using immunogenic peptides or recombinant protein fragments unique to ADCY7. They are validated for specificity through techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF), often with controls such as ADCY7-knockout cell lines.
ADCY7 antibodies are widely used in research to explore its role in diseases like cancer, immune disorders, and neurodegenerative conditions. For example, altered ADCY7 expression or activity has been linked to tumor progression and immune cell dysfunction. High-quality antibodies enable detection of ADCY7 in complex biological samples, aiding mechanistic studies and therapeutic target validation. Commercial ADCY7 antibodies often include detailed validation data, ensuring reliability across applications. Proper storage (e.g., in stabilizing buffers) and adherence to experimental protocols are critical to maintaining antibody performance.
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