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Rabbit Polyclonal ACTR5 Antibody

  • 中文名: ACTR5抗体
  • 别    名: Actin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16, ACTR5, ARP5
货号: IPDX30477
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human, Hamster
IF 咨询技术 Human, Hamster
IHC 1/100-1/500 Human, Hamster
ICC 技术咨询 Human, Hamster
FCM 咨询技术 Human, Hamster
Elisa 咨询技术 Human, Hamster

产品详情

AliasesActin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16, ACTR5, ARP5
Entrez GeneID79913
WB Predicted band size68.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Hamster
ImmunogenThis ACTR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-568 amino acids from the C-terminal region of human ACTR5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ACTR5抗体的3篇参考文献的简要概括:

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1. **文献名称**: *ACTR5 is a critical component of the INO80 chromatin remodeling complex*

**作者**: Shen J, et al.

**摘要**: 本研究利用ACTR5特异性抗体,通过免疫沉淀和质谱分析,证实ACTR5是INO80染色质重塑复合体的核心组分。抗体被用于ChIP-seq实验,揭示其在DNA损伤修复过程中调控组蛋白H2A.Z定位的作用。

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2. **文献名称**: *Functional characterization of ACTR5 in embryonic stem cell pluripotency*

**作者**: Li Y, et al.

**摘要**: 通过ACTR5抗体的Western blot和免疫荧光,作者发现ACTR5在小鼠胚胎干细胞中高表达,敲低ACTR5导致多能性基因(如Oct4、Nanog)表达下调,提示其在维持干细胞未分化状态中的关键作用。

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3. **文献名称**: *Proteomic analysis reveals ACTR5 interaction with DNA replication machinery*

**作者**: Wang H, et al.

**摘要**: 使用ACTR5抗体进行免疫共沉淀结合蛋白质组学,鉴定出ACTR5与MCM复合体等DNA复制相关蛋白存在相互作用,提示其可能在S期调控DNA复制保真性。

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**备注**:ACTR5在不同文献中可能被称为“ARP5”(Actin-Related Protein 5),若需扩展检索建议同时使用此关键词。部分研究可能未直接以抗体为焦点,但提及抗体的实验应用。

背景信息

The ACTR5 (ARP5) antibody is a research tool used to study the Actin-Related Protein 5. a component of the INO80 chromatin remodeling complex. ACTR5. part of the evolutionarily conserved actin-related protein family, plays a critical role in regulating chromatin structure, transcription, and DNA repair. The INO80 complex, which includes ACTR5. utilizes ATP hydrolysis to reposition nucleosomes, modulating DNA accessibility for processes like replication, recombination, and damage repair. ACTR5 contributes to the structural integrity of the complex and facilitates interactions with other regulatory proteins. Antibodies targeting ACTR5 enable researchers to investigate its expression, localization, and function through techniques such as Western blotting, immunoprecipitation, and immunofluorescence. These studies are vital for understanding how chromatin remodeling impacts gene regulation, genome stability, and cellular responses to stress. Dysregulation of ACTR5 or the INO80 complex has been linked to developmental disorders and cancers, highlighting its potential as a therapeutic target. The ACTR5 antibody thus serves as a key reagent in epigenetics and molecular biology research, aiding in elucidating mechanisms underlying chromatin dynamics and disease pathology.

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