| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tetraspanin-6, Tspan-6, A15 homolog, Putative NF-kappa-B-activating protein 321, T245 protein, Tetraspanin TM4-D, Transmembrane 4 superfamily member 6, TSPAN6, TM4SF6 |
| Entrez GeneID | 7105 |
| WB Predicted band size | 27.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TSPAN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176~205 amino acids from the C-terminal region of human TSPAN6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TSPAN6抗体的3篇示例参考文献(内容为虚构，供参考，建议通过学术数据库验证)：
1. **文献名称**: *"TSPAN6 as a Novel Biomarker in Breast Cancer: Expression Analysis Using a Specific Polyclonal Antibody"*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对TSPAN6蛋白的多克隆抗体，并通过免疫组化和Western blot验证其在乳腺癌组织中的高表达，表明TSPAN6可能作为肿瘤侵袭性的潜在标志物。
2. **文献名称**: *"Characterization of a Monoclonal Antibody Targeting TSPAN6 for Functional Studies in Neuronal Development"*
**作者**: Lee J, et al.
**摘要**: 文章报道了一种高特异性抗TSPAN6单克隆抗体的开发，证实其可用于流式细胞术和免疫荧光成像，并揭示TSPAN6在神经元突触形成中的调控作用。
3. **文献名称**: *"TSPAN6 Interaction with Amyloid Precursor Protein (APP): Insights from Co-Immunoprecipitation Assays"*
**作者**: Zhang Y, et al.
**摘要**: 利用TSPAN6抗体进行共免疫沉淀实验，发现TSPAN6与APP在阿尔茨海默病细胞模型中存在直接相互作用，提示其可能参与淀粉样蛋白代谢通路。
4. **文献名称**: *"The Role of TSPAN6 in Immune Regulation: Antibody-Based Knockdown in T-Cell Models"*
**作者**: Johnson R, et al.
**摘要**: 通过抗体介导的蛋白敲低技术，研究证明TSPAN6通过调节T细胞表面受体信号通路影响免疫应答，为自身免疫疾病治疗提供新靶点。
**注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索(关键词：TSPAN6 antibody, TSPAN6 function)。
**Background of TSPAN6 Antibody**
TSPAN6 (Tetraspanin-6) is a member of the tetraspanin superfamily, characterized by four transmembrane domains that mediate protein-protein interactions and regulate cellular processes like signal transduction, adhesion, and membrane organization. TSPAN6 is widely expressed in tissues, including the brain, and plays roles in neuronal development, synaptic function, and intracellular trafficking. It interacts with proteins such as ADAM10 and BACE1. influencing amyloid precursor protein processing, which links it to Alzheimer’s disease pathology.
TSPAN6-specific antibodies are essential tools for studying its expression, localization, and functional mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using TSPAN6 antibodies has revealed its dysregulation in cancers (e.g., glioblastoma, colorectal cancer) and neurological disorders, suggesting potential as a biomarker or therapeutic target. Commercial TSPAN6 antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown. Challenges include ensuring minimal cross-reactivity with other tetraspanins (e.g., TSPAN5 or TSPAN7) due to structural similarities. Recent studies also explore TSPAN6’s role in exosome biogenesis and viral entry mechanisms, broadening its relevance in biomedical research.
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