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Rabbit Polyclonal Phospho-Endophilin(Y80) Antibody

  • 中文名： Phospho-Endophilin(Y80)抗体
  • 别    名： Endophilin-B1, Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1, SH3GLB1, KIAA0491
货号: IPDX30455
Price： ￥1280
数量：
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验证与应用

应用及物种
WB DB: 1/500 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A*68; HLA-A; MHC class I antigen HLA A heavy chain
Entrez GeneID3105
WB Predicted band sizeCalculated MW: 41 kDa; Observed MW: 41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThe antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于Phospho-Endophilin (Y80)抗体的参考文献示例(注：部分文献为假设性描述，实际引用需核实)：

1. **文献名称**：*Tyrosine Phosphorylation of Endophilin A1 Modulates Synaptic Vesicle Endocytosis*

**作者**：Smith J, et al.

**摘要**：该研究通过Phospho-Endophilin(Y80)抗体发现，Src激酶介导的Y80磷酸化增强Endophilin A1与动态素的结合，促进突触囊泡内吞。神经元刺激后，Y80磷酸化水平显著升高。

2. **文献名称**：*EGF Signaling Triggers Endophilin A2 Phosphorylation at Tyrosine 80 to Regulate Receptor Internalization*

**作者**：Lee S, et al.

**摘要**：研究利用Phospho-Endophilin(Y80)抗体证明，表皮生长因子(EGF)激活后，Endophilin A2的Y80位点被磷酸化，从而调控EGFR内吞及下游信号传导。

3. **文献名称**：*Dysregulated Endophilin Y80 Phosphorylation in Parkinson’s Disease Models*

**作者**：Chen R, et al.

**摘要**：在α-synuclein过表达的帕金森病模型中，Phospho-Endophilin(Y80)抗体检测到Y80磷酸化异常，导致突触囊泡回收障碍，提示其与神经退行性病变相关。

4. **文献名称**：*Development of a Phospho-Specific Antibody Targeting Endophilin at Tyrosine 80: Applications in Membrane Trafficking Studies*

**作者**：Zhang H, et al.

**摘要**：该文献详细描述了Phospho-Endophilin(Y80)抗体的开发与验证，证实其特异性及在活细胞成像和Western blot中的应用，为研究内吞机制提供了工具。

(注：以上文献为示例性质，实际研究中请通过学术数据库核实具体信息。)

背景信息

Phospho-Endophilin (Y80) antibody is a specialized tool used to detect the tyrosine 80 phosphorylation site of Endophilin, a protein critical for membrane remodeling and intracellular trafficking. Endophilins, primarily belonging to the Bin-Amphiphysin-Rvs (BAR) domain protein family, are involved in shaping lipid bilayers and facilitating vesicle formation during endocytosis. The Endophilin A subfamily (A1. A2. A3) plays key roles in synaptic vesicle recycling, receptor internalization, and autophagy. Phosphorylation at tyrosine 80 (Y80) in Endophilin A1 regulates its functional interactions, particularly in modulating membrane curvature and recruiting downstream effectors like dynamin or synaptojanin. This post-translational modification is implicated in signaling pathways that influence neuronal communication, receptor trafficking, and cellular adaptation to stimuli. The Phospho-Endophilin (Y80) antibody enables researchers to study the activation status and spatiotemporal dynamics of Endophilin in processes such as clathrin-mediated endocytosis, synaptic plasticity, or disease models like neurodegeneration and cancer. Its applications span Western blotting, immunofluorescence, and immunohistochemistry, aiding in elucidating phosphorylation-dependent mechanisms underlying membrane trafficking and cellular homeostasis.

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