| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A*68; HLA-A; MHC class I antigen HLA A heavy chain |
| Entrez GeneID | 3105 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于TNPO1 (N-term)抗体的参考文献示例(注：以下内容为假设性示例，实际引用需查询具体文献数据库)：
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1. **文献名称**：*Transportin-1 facilitates HIV-1 nuclear import by recognizing viral integrase*
**作者**：L. C. M. Chow et al.
**摘要**：该研究利用TNPO1 (N-term)抗体进行免疫共沉淀实验，证实了TNPO1通过结合HIV-1整合酶促进病毒核转运的机制，揭示了病毒入侵的关键宿主因子。
2. **文献名称**：*TNPO1 modulates TDP-43 cytoplasmic mislocalization in ALS pathogenesis*
**作者**：S. Nakamura et al.
**摘要**：通过免疫荧光和Western blot(使用TNPO1 N端抗体)，研究发现TNPO1功能缺陷导致TDP-43在细胞质异常聚集，与肌萎缩侧索硬化症(ALS)的病理过程相关。
3. **文献名称**：*Characterization of a polyclonal antibody targeting the N-terminal domain of TNPO1*
**作者**：A. B. Smith et al.
**摘要**：本文验证了一种TNPO1 N端多克隆抗体的特异性，通过敲低实验和肽段竞争性结合证实其在免疫组化与蛋白质互作研究中的可靠性。
4. **文献名称**：*Transportin-1 promotes cancer metastasis via regulation of Snail1 nuclear export*
**作者**：J. H. Lee et al.
**摘要**：研究使用TNPO1 (N-term)抗体发现，TNPO1通过调控Snail1的核质穿梭增强肿瘤细胞的侵袭能力，为癌症转移提供了新的治疗靶点。
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建议通过PubMed或Web of Science以“TNPO1 antibody”“N-terminal”等关键词检索最新文献以获取准确信息。
TNPO1 (Transportin-1), also known as Importin-β2. is a nuclear transport receptor belonging to the importin-β family. It mediates the nuclear import of specific cargo proteins containing a proline-tyrosine nuclear localization signal (PY-NLS), including RNA-binding proteins, splicing factors, and certain viral proteins. The TNPO1 (N-term) antibody is designed to target the N-terminal region of TNPO1. which plays a critical role in cargo recognition and binding. This antibody is widely used in research to study TNPO1’s expression, localization, and function in cellular processes such as nucleocytoplasmic transport, RNA metabolism, and viral infection mechanisms.
TNPO1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and HIV pathogenesis, where it facilitates viral integration by transporting HIV-1 preintegration complexes into the nucleus. The antibody’s specificity for the N-terminal domain makes it valuable for distinguishing TNPO1 from other importin family members and assessing post-translational modifications or interactions within this region. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation, often using human, mouse, or rat samples. Understanding TNPO1 dynamics through this antibody aids in elucidating its regulatory mechanisms and therapeutic potential in disease contexts.
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