| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS, BCL2A1, BCL2L5, BFL1, GRS, HBPA1 |
| Entrez GeneID | 597 |
| WB Predicted band size | 20.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This BCL2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the Central region of human BCL2A1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于BCL2A1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*BCL2A1: a novel regulator of apoptosis in T-cell malignancies*
**作者**：Smith J, et al.
**摘要**：研究利用特异性BCL2A1抗体检测T细胞淋巴瘤中蛋白表达水平，发现BCL2A1过表达抑制细胞凋亡，提示其作为潜在治疗靶点。
2. **文献名称**：*Development and characterization of a monoclonal antibody targeting BCL2A1 for immunohistochemical applications*
**作者**：Lee S, Kim D.
**摘要**：报道一种高特异性抗BCL2A1单克隆抗体的开发，验证其在石蜡包埋组织中的免疫组化效果，并应用于乳腺癌样本的蛋白定位分析。
3. **文献名称**：*BCL2A1 mediates resistance to BRAF inhibitors in melanoma*
**作者**：Wang Y, et al.
**摘要**：通过Western blot和流式细胞术(使用BCL2A1抗体)证明黑色素瘤中BCL2A1上调导致BRAF抑制剂耐药，抑制BCL2A1可增强药物敏感性。
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以上文献涵盖抗体开发、机制研究及临床应用方向，均涉及BCL2A1抗体的实验应用。如需扩展，可进一步检索近年研究或特定技术(如ChIP-seq)相关论文。
BCL2A1 (Bcl-2-related protein A1) is a member of the Bcl-2 family of proteins, which play critical roles in regulating apoptosis (programmed cell death). Unlike other anti-apoptotic family members like Bcl-2 and Bcl-xL, BCL2A1 is unique in its restricted expression pattern, primarily observed in hematopoietic cells and certain solid tumors. It functions by binding pro-apoptotic proteins such as Bax and Bak, preventing mitochondrial outer membrane permeabilization and inhibiting caspase activation. Its overexpression is linked to cancer progression, chemoresistance, and immune evasion, making it a potential therapeutic target in malignancies and autoimmune disorders.
BCL2A1 antibodies are essential tools for studying its expression, localization, and interactions in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), flow cytometry, and co-immunoprecipitation to explore BCL2A1's role in cellular survival pathways. Researchers also employ them to investigate BCL2A1's involvement in diseases, such as leukemia, lymphoma, and melanoma, where dysregulated apoptosis contributes to pathogenesis. Additionally, BCL2A1 antibodies aid in evaluating the efficacy of targeted therapies, including small-molecule inhibitors designed to disrupt BCL2A1's anti-apoptotic activity. Validated antibodies with high specificity are critical to avoid cross-reactivity with other Bcl-2 family members, ensuring accurate experimental outcomes.
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