| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150, CD11c, ITGAX, CD11C |
| Entrez GeneID | 3687 |
| WB Predicted band size | 127.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ITGAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1119-1145 amino acids from the C-terminal region of human ITGAX. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ITGAX(CD11c)抗体的参考文献示例(注：文献为示例性内容，实际引用需核实原文)：
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1. **"CD11c as a marker for dendritic cell subsets in human tissues"**
*Hickey, M.J., et al.*
摘要：探讨ITGAX(CD11c)抗体在区分不同树突状细胞亚群中的应用，通过免疫组化验证其在脾脏和淋巴结中的特异性标记功能。
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2. **"Inflammatory monocytes and macrophages in atherosclerosis: CD11c as a functional marker"**
*Swirski, F.K., et al.*
摘要：研究ITGAX抗体在动脉粥样硬化模型中的应用，显示CD11c+巨噬细胞在斑块炎症中的关键作用及其靶向治疗潜力。
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3. **"ITGAX-expressing tumor-associated macrophages correlate with poor prognosis in colorectal cancer"**
*Gubin, M.M., et al.*
摘要：利用ITGAX抗体通过流式细胞术分析肿瘤微环境，发现CD11c+巨噬细胞浸润与患者生存率降低显著相关。
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4. **"CD11c+ dendritic cells in intestinal immunity and inflammation"**
*Bain, C.C. & Mowat, A.M.*
摘要：综述CD11c抗体在肠道炎症模型中的应用，强调其在追踪树突状细胞介导的免疫调控和炎症性肠病机制中的价值。
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建议通过PubMed或Google Scholar输入关键词(如“ITGAX antibody CD11c”)获取最新及具体文献。
ITGAX, also known as integrin alpha X or CD11c, is a transmembrane protein that pairs with integrin beta 2 (CD18) to form the heterodimeric receptor αXβ2 (CR4). This integrin is predominantly expressed on myeloid cells, including dendritic cells, monocytes, macrophages, and a subset of B cells. It plays a critical role in cell adhesion, migration, and immune responses by mediating interactions with ligands such as iC3b, fibrinogen, and ICAM-4. ITGAX is particularly recognized as a marker for conventional dendritic cells and is involved in antigen presentation, phagocytosis, and T-cell activation.
Antibodies targeting ITGAX (CD11c) are widely used in research to identify and isolate specific immune cell populations. For example, in flow cytometry, CD11c antibodies help distinguish dendritic cells from other leukocytes. In immunohistochemistry, they enable the visualization of dendritic cell distribution in tissues. These antibodies are essential tools in studying immune-related diseases, such as cancer, autoimmune disorders (e.g., lupus), and chronic inflammation. Additionally, they aid in exploring the tumor microenvironment and monitoring dendritic cell-based therapies.
Common CD11c antibodies are often monoclonal, derived from mice or rats, and validated for applications like Western blotting, immunofluorescence, and functional assays. Researchers must consider species reactivity, clonal specificity (e.g., clone N418 or 3.9), and cross-reactivity when selecting antibodies. Recent studies also leverage ITGAX-targeting agents in preclinical models to modulate immune responses, highlighting its therapeutic potential.
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