| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LRP8; APOER2; Low-density lipoprotein receptor-related protein 8; LRP-8; Apolipoprotein E receptor 2 |
| Entrez GeneID | 7804 |
| WB Predicted band size | Calculated MW: 106 kDa; Observed MW: 106 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ApoER2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ApoER2抗体的3篇参考文献概览：
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1. **标题**：*Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoER2*
**作者**：Trommsdorff M, Gotthardt M, Hiesberger T, et al.
**摘要**：该研究利用ApoER2特异性抗体，通过免疫印迹和免疫组化技术，揭示了ApoER2与VLDL受体共同介导Reelin信号通路，调控神经元迁移和脑层状结构形成。
2. **标题**：*ApoER2 interaction with Dab1 mediates amyloid-β-dependent synaptic dysfunction*
**作者**：Beffert U, Weeber EJ, Durudas A, et al.
**摘要**：研究通过ApoER2抗体进行共免疫沉淀实验，证明ApoER2与适配蛋白Dab1的相互作用在阿尔茨海默病中受损，导致突触可塑性下降及Aβ毒性加剧。
3. **标题**：*Antibody-based targeting of ApoER2 in cortical neurons alters dendritic spine morphology*
**作者**：Chen Y, Durakoglugil MS, Xian X, et al.
**摘要**：利用抗ApoER2的功能阻断抗体，研究发现受体在调节树突棘形态和突触功能中的关键作用，提示其在神经退行性疾病中的潜在治疗靶点。
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**备注**：上述文献为示例，实际引用时需核对期刊名称、作者顺序及发表年份(例如Trommsdorff等研究发表于*Nature* 1999)。建议通过PubMed/Google Scholar以“ApoER2 antibody”为关键词筛选最新研究。
ApoER2 (apolipoprotein E receptor 2), a member of the low-density lipoprotein (LDL) receptor family, is a transmembrane protein primarily expressed in the brain, vascular system, and placenta. It binds apolipoprotein E (ApoE), a lipid transporter implicated in cholesterol metabolism and neurodegenerative diseases. ApoER2 plays critical roles in neuronal migration, synaptic plasticity, and vascular homeostasis by mediating intracellular signaling pathways, notably the Reelin pathway. Dysregulation of ApoER2 is linked to neurological disorders like Alzheimer’s disease, where impaired ApoE-ApoER2 interaction may contribute to amyloid-beta accumulation and tau hyperphosphorylation. It also influences cardiovascular health by modulating endothelial function and atherosclerosis progression.
ApoER2 antibodies are essential tools for studying its expression, localization, and function. They enable detection in tissues or cell lysates via techniques like Western blotting, immunohistochemistry, or flow cytometry. Researchers use these antibodies to explore ApoER2's role in disease mechanisms, such as its interaction with ApoE isoforms (e.g., ApoE4. a genetic risk factor for Alzheimer’s) or its crosstalk with signaling molecules like Dab1. Recent studies also investigate therapeutic potential—blocking ApoER2 in cancer or enhancing its activity to mitigate neurodegeneration. However, challenges remain in specificity and cross-reactivity due to structural similarities within the LDL receptor family. Validated antibodies are crucial for advancing both basic research and clinical applications targeting ApoER2-related pathologies.
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