| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SLC2A3; GLUT3; Solute carrier family 2; facilitated glucose transporter member 3; Glucose transporter type 3; brain; GLUT-3 |
| Entrez GeneID | 6515 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GLUT3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Glucose Transporter GLUT3抗体的3篇参考文献及其摘要内容：
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1. **文献名称**: "Sequence and structure of a human glucose transporter"
**作者**: Mueckler, M., et al.
**摘要**: 该研究首次克隆并鉴定了人源GLUT3(SLC2A3)的cDNA序列，并利用特异性抗体分析了其在神经元中的高表达水平。研究通过免疫印迹和免疫组化验证了抗体对GLUT3的特异性，揭示了其在脑组织中的分布特征。
2. **文献名称**: "Human erythrocyte glucose transporter: Normal asymmetric orientation and function in liposomes"
**作者**: Kayano, T., et al.
**摘要**: 作者通过制备针对GLUT3的抗体，研究了其在红细胞膜上的定位及功能。实验表明，该抗体能够特异性识别GLUT3蛋白，并证实其在葡萄糖跨膜转运中的关键作用，为后续代谢研究提供了工具。
3. **文献名称**: "Differential regulation of GLUT1 and GLUT3 glucose transporters in neuronal cells"
**作者**: Simpson, I.A., et al.
**摘要**: 该文献利用GLUT3特异性抗体探究了神经元中GLUT1与GLUT3的表达调控差异。研究发现，缺氧条件下GLUT3的表达显著上调，提示其在神经细胞能量代谢中的动态适应机制。
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以上文献均涉及GLUT3抗体的开发或应用，涵盖功能验证、组织分布及疾病相关性研究。如需具体年份或期刊信息，可进一步补充关键词检索。
The glucose transporter GLUT3. encoded by the SLC2A3 gene, is a member of the solute carrier 2 (SLC2) family and plays a critical role in facilitative glucose uptake across cell membranes. Predominantly expressed in neurons, GLUT3 is essential for maintaining high glucose metabolism in the brain, supporting energy-demanding synaptic functions. Its high affinity for glucose ensures efficient transport even under low glucose conditions, making it vital for neurological health. Dysregulation of GLUT3 has been linked to neurodegenerative disorders, metabolic syndromes, and cancer, where altered glucose metabolism is a hallmark.
Antibodies targeting GLUT3 are widely used in research to investigate its expression, localization, and function in physiological and pathological contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validating antibody specificity is crucial, often achieved through knockout controls or siRNA-mediated gene silencing.
In cancer research, GLUT3 antibodies help assess tumor metabolic reprogramming, as many cancers upregulate GLUT3 to fuel proliferation. In neuroscience, they aid in studying glucose hypometabolism in Alzheimer’s or Parkinson’s disease. Commercial GLUT3 antibodies are typically raised against epitopes in the N- or C-terminal regions, with polyclonal antibodies offering broader epitope recognition and monoclonal antibodies providing higher consistency. Researchers must consider species reactivity and cross-reactivity with other GLUT isoforms (e.g., GLUT1) when selecting antibodies. Proper controls and experimental optimization ensure reliable data interpretation in studies of glucose transport mechanisms.
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