| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NR4A1; GFRP1; HMR; NAK1; Nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3 |
| Entrez GeneID | 3164 |
| WB Predicted band size | Calculated MW: 64 kDa; Observed MW: 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human NUR77 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于NUR77抗体的代表性文献摘要信息(文献标题和作者为虚构示例，供参考格式)：
1. **"Development and Validation of a Novel Monoclonal Antibody for Specific Detection of NUR77 in Human Tissues"**
*作者：Zhang L et al.*
**摘要**：本研究开发了一种针对人源NUR77蛋白的高特异性单克隆抗体，通过免疫印迹和免疫组化验证其在多种组织中的检测能力，确认其在癌症研究中的应用潜力。
2. **"NUR77 Antibody-Based Screening Reveals Its Role in Apoptosis Signaling Pathways"**
*作者：Kim S et al.*
**摘要**：利用特异性NUR77抗体，研究发现NUR77在细胞凋亡过程中易位至线粒体并与Bcl-2相互作用，为靶向NUR77的癌症治疗提供了机制依据。
3. **"Cross-Reactivity Analysis of Commercial NUR77 Antibodies: Implications for Experimental Reproducibility"**
*作者：Johnson R et al.*
**摘要**：系统评估了市售NUR77抗体的交叉反应性，发现部分抗体存在非特异性结合问题，强调选择高特异性抗体对研究结果可靠性的重要性。
(注：以上文献为示例，实际引用时请通过PubMed或学术数据库检索真实文献。)
**Background of NUR77 Antibody**
NUR77 (Nuclear Receptor Subfamily 4 Group A Member 1. NR4A1) is an immediate-early response gene-encoded protein belonging to the steroid/thyroid hormone nuclear receptor superfamily. It functions as a transcription factor regulating diverse biological processes, including cell proliferation, apoptosis, inflammation, and metabolism. NUR77 is unique in its ability to act as both a nuclear receptor and a cytoplasmic signaling molecule, depending on cellular context and post-translational modifications.
NUR77 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological conditions. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to detect NUR77 in tissues or cultured cells. Given its role in diseases like cancer, metabolic disorders, and autoimmune conditions, NUR77 antibodies help researchers explore its regulatory mechanisms in pathways such as NF-κB, MAPK, and apoptosis.
Validated NUR77 antibodies specifically recognize conserved epitopes across species (human, mouse, rat) and distinguish between isoforms or modified states (e.g., phosphorylated forms). Their application has revealed NUR77’s dynamic shuttling between the nucleus and cytoplasm, its interaction with co-regulators, and its potential as a therapeutic target or biomarker in disease models.
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