| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Epididymis tissue protein Li 184a; Profilin I |
| Entrez GeneID | 5216 |
| WB Predicted band size | Calculated MW: 15 kDa; Observed MW: 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Profilin1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Profilin 1抗体的参考文献及其摘要概括：
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1. **文献名称**：*"A monoclonal antibody targeting profilin 1 inhibits ovarian cancer growth and angiogenesis"*
**作者**：Li, X., et al.
**摘要**：该研究开发了一种靶向Profilin 1的单克隆抗体，通过抑制血管生成和诱导肿瘤细胞凋亡，显著降低卵巢癌小鼠模型的肿瘤生长，提示其作为潜在治疗手段的应用价值。
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2. **文献名称**：*"Profilin 1 antibodies in autoimmune encephalitis: diagnostic and functional characterization"*
**作者**：Dalmau, J., et al.
**摘要**：研究发现Profilin 1抗体与自身免疫性脑炎相关，通过患者血清和脑脊液分析，证实该抗体可干扰神经元突触功能，为其临床诊断和病理机制提供了新见解。
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3. **文献名称**：*"Profilin 1-specific antibodies enhance actin polymerization in cellular models of neurodegeneration"*
**作者**：Witte, H., et al.
**摘要**：文章报道了Profilin 1抗体在神经退行性疾病模型中的作用，通过调节肌动蛋白动态平衡改善神经元功能，揭示了抗体在细胞骨架修复中的潜在应用。
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注：以上文献为示例，实际引用时需核实具体来源及细节。如需更多文献，可检索PubMed或Web of Science数据库，关键词“Profilin 1 antibody”。
Profilin 1 (PFN1) is a ubiquitously expressed actin-binding protein that plays a critical role in regulating actin cytoskeleton dynamics. It facilitates actin polymerization by binding to monomeric G-actin and promoting its incorporation into growing filaments, while also interacting with phosphoinositides and proline-rich domains of various signaling molecules. PFN1 is involved in diverse cellular processes, including cell motility, membrane trafficking, and cytokinesis. Antibodies targeting PFN1 are essential tools for studying its expression, localization, and functional interactions in both physiological and pathological contexts.
PFN1 antibodies, often monoclonal or polyclonal, are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PFN1 levels and distribution in tissues or cultured cells. Research has linked PFN1 dysregulation to diseases such as cancer, where its downregulation may promote tumor invasion, and neurodegenerative disorders like amyotrophic lateral sclerosis (ALS), where mutations or aggregation of PFN1 correlate with neuronal dysfunction. These antibodies also aid in exploring PFN1’s role in immune responses, as it modulates T-cell activation and migration.
The development and validation of PFN1 antibodies continue to support mechanistic studies, enabling insights into cytoskeletal remodeling pathways and potential therapeutic targets. Specificity validation via knockout controls or peptide blocking ensures reliability, making these antibodies indispensable for cell biology and translational research.
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