| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36 |
| Entrez GeneID | 302 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Annexin A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Annexin A2抗体的3篇代表性文献摘要信息：
1. **《Annexin A2: A multifunctional calcium- and membrane-binding protein in cell proliferation and cancer》**
- Gerke et al. (2005)
- 综述了Annexin A2在细胞膜组织、胞吐及肿瘤转移中的作用，强调其通过结合细胞骨架和膜脂调控肿瘤微环境，提示其抗体可用于癌症研究及靶向治疗开发。
2. **《Autoantibodies to Annexin A2 in systemic autoimmune diseases》**
- Mussalam et al. (2012)
- 发现Annexin A2抗体与系统性红斑狼疮(SLE)和抗磷脂综合征相关，提示其可能作为自身免疫疾病的血清标志物，并参与血管炎症反应。
3. **《Annexin A2 mediates endothelial cell activation by neutrophil-derived extracellular vesicles》**
- Ling et al. (2014)
- 研究显示Annexin A2抗体可阻断中性粒细胞胞外囊泡诱导的内皮细胞活化，证实其在炎症信号传导中的关键作用，为治疗血管损伤提供潜在靶点。
4. **《Annexin A2 antibodies in the diagnosis of acute promyelocytic leukemia》**
- Menell et al. (1999)
- 提出Annexin A2抗体可作为急性早幼粒细胞白血病(APL)的辅助诊断工具，因其在APL细胞表面高表达，与凝血异常相关。
以上文献涵盖Annexin A2抗体的基础功能、疾病机制及临床应用研究方向。
Annexin A2 is a calcium-dependent phospholipid-binding protein belonging to the annexin superfamily, which plays diverse roles in cellular processes such as exocytosis, endocytosis, cell adhesion, and signal transduction. It exists as a monomer or forms a heterotetrameric complex with S100A10 (p11), enabling interactions with phospholipid membranes, cytoskeletal components, and extracellular ligands. Annexin A2 is implicated in regulating fibrinolysis by binding tissue plasminogen activator (tPA) and plasminogen, facilitating plasmin generation and extracellular matrix remodeling. It also participates in membrane repair, vesicle trafficking, and actin dynamics. Dysregulation of Annexin A2 has been linked to cancer progression, angiogenesis, inflammation, and viral entry mechanisms (e.g., HIV, influenza).
Annexin A2-specific antibodies are essential tools for studying its expression, localization, and functional interactions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation to detect Annexin A2 in tissues or cell lines. In research, they help explore its role in diseases: elevated Annexin A2 levels correlate with tumor metastasis in cancers (e.g., breast, pancreatic, glioblastoma), while reduced expression is observed in autoimmune disorders and cardiovascular conditions. Some therapeutic strategies target Annexin A2 or its signaling partners, making specific antibodies critical for validating target engagement and biomarker analysis. Validation of antibody specificity (via knockout controls) is crucial due to structural homology among annexin family members.
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