| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CSNK2B; CK2N; G5A; Casein kinase II subunit beta; CK II beta; Phosvitin; Protein G5a |
| Entrez GeneID | 1460 |
| WB Predicted band size | Calculated MW: 25 kDa; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Casein Kinase 2 beta |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Casein Kinase 2 beta (CK2β) 抗体的3篇参考文献示例(文献信息为虚构示例，仅供格式参考)：
1. **文献名称**: "Casein Kinase 2 beta subunit regulates DNA damage response via phosphorylation of 53BP1"
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性CK2β抗体，通过免疫沉淀和Western blot分析，揭示了CK2β通过磷酸化DNA修复蛋白53BP1调控DNA损伤应答的分子机制。
2. **文献名称**: "Development and validation of a monoclonal antibody targeting the C-terminal domain of CK2β for cancer biomarker studies"
**作者**: Lee JH, et al.
**摘要**: 文章报道了一种针对CK2β C端结构域的高效单克隆抗体的开发与验证，并证明其在多种癌症组织样本中检测CK2β过表达的应用潜力。
3. **文献名称**: "CK2β modulates Wnt/β-catenin signaling by interacting with Dishevelled proteins"
**作者**: García-Ruiz C, et al.
**摘要**: 通过免疫荧光染色和共定位实验(使用CK2β特异性抗体)，研究发现CK2β通过结合Dishevelled蛋白调控Wnt/β-catenin信号通路活性，影响胚胎发育过程。
(注：以上文献信息为模拟生成，实际引用需查询真实数据库如PubMed。)
Casein Kinase 2 beta (CK2β) is a regulatory subunit of the Casein Kinase 2 (CK2) complex, a highly conserved serine/threonine protein kinase ubiquitously expressed in eukaryotic cells. The CK2 holoenzyme typically exists as a heterotetramer composed of two catalytic subunits (α and/or α') and two regulatory β subunits. While the α/α' subunits mediate enzymatic activity, the β subunit plays a critical role in stabilizing the complex, modulating substrate specificity, and regulating kinase activity. CK2β also influences subcellular localization, protein-protein interactions, and participates in diverse cellular processes, including cell proliferation, apoptosis, DNA repair, and circadian rhythm regulation.
CK2β antibodies are essential tools for studying the expression, localization, and functional dynamics of the CK2 complex. These antibodies are widely used in techniques such as Western blotting, immunoprecipitation, immunofluorescence, and co-immunoprecipitation assays to investigate CK2β interactions with catalytic subunits or other binding partners. Dysregulation of CK2. including altered CK2β expression or post-translational modifications, has been implicated in pathological conditions such as cancer, neurodegenerative diseases, and viral infections. For example, elevated CK2β levels are observed in multiple cancers, where it promotes tumor growth and chemoresistance. Researchers also utilize CK2β-specific antibodies to explore its non-canonical roles independent of the CK2 holoenzyme, such as involvement in Wnt signaling or p53 regulation. Commercial CK2β antibodies are typically raised against conserved epitopes in humans, mice, or rats, with validation across species to support cross-disciplinary research.
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