| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T2-cadherin; CDH10 |
| Entrez GeneID | 1008 |
| WB Predicted band size | Calculated MW: 88 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human cadherin 10 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Cadherin 10(CDH10)抗体的参考文献及其核心内容概括：
1. **文献名称**: *Cadherin-10 regulates axon guidance and neuroblast migration during cortical development*
**作者**: Hayano Y, et al.
**摘要**: 该研究使用CDH10特异性抗体揭示其在胚胎期小鼠皮层神经元迁移中的作用，证明CDH10通过介导细胞间黏附调控神经前体细胞的定向迁移及轴突导向。
2. **文献名称**: *Expression profiling of cadherins in human gliomas identifies CDH10 as a biomarker related to epithelial-mesenchymal transition*
**作者**: Zhang Y, et al.
**摘要**: 通过CDH10抗体进行免疫组化分析，发现其在高级别胶质瘤中表达显著上调，且与肿瘤侵袭性和EMT(上皮间质转化)标志物相关，提示其作为胶质瘤恶性进展的潜在生物标志物。
3. **文献名称**: *A novel role for cadherin 10 in cancer metastasis suppression*
**作者**: Li H, et al.
**摘要**: 利用CDH10抗体在结直肠癌细胞模型中发现，CDH10通过抑制Wnt/β-catenin信号通路降低肿瘤细胞迁移能力，其表达缺失与患者肝转移风险增加相关。
注：以上为虚拟文献案例，实际研究中建议通过PubMed或Web of Science以“CDH10 antibody”为关键词检索最新实证论文。
Cadherin 10 (CDH10), a member of the classical cadherin superfamily, is a calcium-dependent cell adhesion protein encoded by the CDH10 gene. It plays crucial roles in tissue morphogenesis, neuronal circuit formation, and maintaining cellular polarity by mediating homophilic cell-cell interactions. As a type II cadherin, it features extracellular cadherin repeats for calcium-binding, a transmembrane domain, and a cytoplasmic tail that interacts with catenins to regulate cytoskeletal dynamics. CDH10 is highly expressed in the developing nervous system, particularly in brain regions associated with synaptic connectivity, and its dysregulation has been linked to neurodevelopmental disorders, including autism spectrum disorders.
CDH10 antibodies are essential tools for studying its expression patterns, localization, and functional roles. These antibodies, often targeting specific extracellular or intracellular epitopes, enable applications like Western blotting, immunohistochemistry, and immunofluorescence. In cancer research, CDH10 antibodies help investigate its dual role as both a tumor suppressor and promoter, depending on context—e.g., reduced expression in glioblastoma versus overexpression in certain lung cancers. They also serve as potential biomarkers for assessing tumor progression and therapeutic responses. Recent studies emphasize their utility in decoding CDH10's involvement in neural plasticity and metastasis, bridging structural biology with translational medicine.
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