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Rabbit Monoclonal NDUFA1 Antibody

  • 中文名： NDUFA1抗体
  • 别    名： MWFE; ZNF183; CI-MWFE
货号: IPDX21719
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMWFE; ZNF183; CI-MWFE
Entrez GeneID4694
WB Predicted band sizeCalculated MW: 8 kDa; Observed MW: 8 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human NDUFA1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于NDUFA1抗体的参考文献示例(注：以下为虚构示例，实际文献需通过学术数据库查询)：

1. **文献名称**：*"NDUFA1 Antibody Validation in Mitochondrial Complex I Deficiency Disorders"*

**作者**：Smith J, et al.

**摘要**：本研究通过Western blot和免疫荧光技术验证了NDUFA1抗体的特异性，发现其在检测患者成纤维细胞中线粒体复合物I亚基缺失中的敏感性，为线粒体疾病诊断提供工具。

2. **文献名称**：*"Immunohistochemical Analysis of NDUFA1 in Neurodegenerative Brains"*

**作者**：Lee S, et al.

**摘要**：利用NDUFA1抗体对阿尔茨海默病模型脑组织进行染色，发现NDUFA1蛋白表达显著降低，提示其与线粒体功能障碍及神经元退行性变相关。

3. **文献名称**：*"NDUFA1 as a Biomarker in Colorectal Cancer: An Antibody-Based Study"*

**作者**：Garcia R, et al.

**摘要**：通过NDUFA1抗体进行免疫组化分析，揭示结直肠癌组织中NDUFA1表达下调与患者预后不良及肿瘤代谢重编程的相关性。

4. **文献名称**：*"Structural Insights into NDUFA1 Role in Complex I Assembly Using Epitope-Specific Antibodies"*

**作者**：Wang Y, et al.

**摘要**：开发表位特异性NDUFA1抗体，解析其在复合物I组装中的功能，并通过敲除模型证明其突变导致氧化磷酸化缺陷。

**建议**：通过PubMed、Web of Science等平台，以“NDUFA1 antibody”或“NDUFA1 + [疾病/技术]”为关键词检索真实文献。

背景信息

The NDUFA1 antibody is a tool used to detect the NDUFA1 protein, a critical subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) in the electron transport chain. Complex I, located in the mitochondrial inner membrane, facilitates NADH oxidation and proton translocation, driving ATP synthesis. NDUFA1 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1) is encoded by the nuclear NDUFA1 gene and is essential for Complex I assembly and stability. Antibodies targeting NDUFA1 are widely employed in research to study protein expression, localization, and dysfunction in mitochondrial disorders. Altered NDUFA1 levels or mutations are linked to pathologies such as Leigh syndrome, neurodegenerative diseases, and cancer, reflecting its role in oxidative phosphorylation. These antibodies are utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess mitochondrial health, diagnose Complex I deficiencies, or explore disease mechanisms. Additionally, they aid in understanding how NDUFA1 interacts with other subunits or regulatory factors, providing insights into mitochondrial metabolism and stress responses. As mitochondrial dysfunction is implicated in aging and metabolic syndromes, NDUFA1 antibodies serve as vital reagents for both basic research and clinical investigations.

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